Inhibitory Effect of Fermented Grape Pomace on Degranulation in RBL-2H3 Cells and an Analysis of Its Active Ingredients
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the anti-allergic effect of fermented grape pomace from Vitis vinifera Koshu (FG), using rat basophilic leukemia (RBL-2H3) cells. FG showed greater inhibitory effect on degranulation than Lactobacillus plantarum NB strain (NB strain), which was used for fermentation, and grape pomace (G). Furthermore, we separated FG into three fractions with distilled water containing 0.1% trifluoroacetic acid (acidified water) (F1), ethyl acetate (F2) and methanol (F3) in order to investigate the active ingredients in FG, and analyzed their inhibitory mechanisms on degranulation. The F2 sample, which contained mainly low polymerized phenolic ingredients, showed a strong inhibitory effect, whereas the F3 sample, which contained mainly polymeric proanthocyandins, showed the highest inhibitory effect among all samples. It was confirmed that phenolic ingredients in FG act on various stages of degranulation. These results suggest that FG may exert anti-inflammatory and anti-allergic effects by acting on various stages of the degranulation response of mast cells.
- 2011-05-01
著者
-
Nakamura Kazutoshi
Department Of Community Preventive Medicine Graduate School Of Medical And Dental Sciences Niigata U
-
Hamauzu Yasunori
Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu University
-
Kawahara Takeshi
Department Of Chemistry Biology And Marine Science Graduate School Of Science And Engineering Univer
-
Kawahara Takeshi
Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu University
-
KONDO Koyuki
Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
-
SANSAWA Hiroshi
Nihon Bio Corporation, Shinjuku center building
-
SUZUKI Mitsumasa
Nihon Bio Corporation, Shinjuku center building
-
YASUI Hisako
Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
-
Kondo Koyuki
Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu University
-
Yasui Hisako
Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu University
-
Suzuki Mitsumasa
Nihon Bio Corporation Shinjuku Center Building
-
Nakamura Kazutoshi
Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu University
-
Sansawa Hiroshi
Nihon Bio Corporation Shinjuku Center Building
関連論文
- Development of a Simple Food Frequency Questionnaire to Estimate Intakes of Calcium and Other Nutrients for the Prevention and Management of Osteoporosis
- Sleep-Wake Rhythm and Physical Fitness in Relation to Activities of Daily Living in Stroke Survivors Residing At Home
- Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis(Molecular and Cell Biology)
- Sex, age, and anthropometric differences in the prevalence of metabolic syndrome in Japan : a comparison between the Japan criteria and NCEP-ATPIII criteria
- Appropriate Waist Circumference Cutoff Values for Persons with Multiple Cardiovascular Risk Factors in Japan : a Large Cross-sectional Study
- Effect of Quinapril on Apoptosis in Human Vascular Endothelial Cells via Bradykinin, Heat Shock Protein 90 and NOX Dependent Pathway
- AN UNDESCRIBED FALSE SPIDER CRAB OF THE GENUS NEORHYNCHOPLAX (CRUSTACEA: DECAPODA: BRACHYURA) FROM IRIOMOTE ISLAND, THE RYUKYU ISLANDS, JAPAN(Taxonomy and Systematics,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of
- Effects of Japan Sea Proper Water on the Growth of Legionella pneumophila, Escherichia coli, and Staphylococcus aureus
- Long-Term Suicide Mortality Rates Decrease in Men and Increase in Women after the Niigata-Chuetsu Earthquake in Japan
- Threshold value of serum 25-hydroxyvitamin D concentration in relation to elevated serum parathyroid hormone concentrations in elderly Japanese women
- Intakes of Calcium and Other Nutrients Related to Bone Health in Japanese Female College Students : A Study Using the Duplicate Portion Sampling Method
- Independent Predictors of Knee Osteoarthritis in an Elderly Japanese Population : A Multivariate Analysis
- Efficacy of Optimization of Vitamin D in Preventing Osteoporosis and Osteoporotic Fractures : A Systematic Review
- Vitamin D and Prevention of Osteoporosis : Japanese Perspective
- Does Back Pain Predict Subsequent Fracture in Postmenopausal Women?
- Bone fracture in physically disabled children attending schools for handicapped children in Japan
- Microscopic hematuria is associated with low bone mineral density in aged women and men
- Prevalence of attention-deficit/hyperactivity disorder (ADHD) symptoms in preschool children : discrepancy between parent and teacher evaluations
- Urinary Protein Excretion after Low-Intensity Walking in Healthy Japanese Elderly Women
- Contamination of the Shinano River Water with Mutagenic Substances after the Niigata Chuetsu Earthquake
- Effects of Desalted Deep Seawater on Hematologic and Blood Chemical Values in Mice
- Changes in Plasma Lactate and Pyruvate Concentrations after Taking a Bath in Hot Deep Seawater
- Effects of Hot Deep Seawater Bathing on the Immune Cell Distribution in Peripheral Blood from Healthy Young Men
- Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care
- The Usefulness of Day-Service in Maintaining General Nutritional Status in Elderly Japanese : A Longitudinal Study
- Serum 25-hydroxyvitamin D levels and activities of daily living in noninstitutionalized elderly Japanese requiring care
- Health Characteristics of Elderly Japanese Requiring Care at Home
- Factors Affecting Short-Term Mortality in Very Low Birth Weight Infants in Japan
- Inhibitory Effect of Fermented Grape Pomace on Degranulation in RBL-2H3 Cells and an Analysis of Its Active Ingredients
- Vitamin D Nutritional Status of Women Living on a Solitary Island in Japan : A Population-Based Study
- Influence of local vibration on finger functions of forest workers
- Inhibitory effects of Goishi tea against influenza virus infection
- Serum 25-Hydroxyvitamin D Concentrations and Season-Specific Correlates in Japanese Adults
- Positive predictive values for self-reported fractures in an adult Japanese population
- Determination of whether the association between serum albumin and activities of daily living in frail elderly people is causal
- Dietary Reference Intakes for Japanese 2010: Macrominerals
- Dietary Reference Intakes for Japanese 2010: Lifestage
- Change in bone mineral density and tooth loss in Japanese community-dwelling postmenopausal women : a 5-year cohort study