Herb Formula "Fufangqishe-Pill" Prevents Upright Posture-Induced Intervertebral Disc Degeneration at the Lumbar in Rats
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概要
- 論文の詳細を見る
Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II–collagen level, decreased type X–collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.
- 社団法人 日本薬理学会の論文
- 2010-05-20
著者
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Hou Wei
Department of Hepatology, Capital University of Medical Science Affiliated Beijing You An Hospital
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Shi Qi
Institute Of Spine Shanghai University Of Traditional Chinese Medicine
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WANG Yong-Jun
Institute of Spine, ShangHai University of Traditional Chinese Medicine
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BIAN Qin
Institute of Spine, ShangHai University of Traditional Chinese Medicine
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LI Chen-Guang
Institute of Spine, ShangHai University of Traditional Chinese Medicine
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Wang Yong-jun
Institute Of Spine Shanghai University Of Traditional Chinese Medicine
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Hou Wei
Department Of Electrical Engineering National University Of Singapore
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Li Chen-guang
Institute Of Spine Shanghai University Of Traditional Chinese Medicine
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Liang Qian-Qian
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin
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Xi Zhi-Jie
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin
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Bian Qin
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin
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Cui Xue-Jun
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin
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Li Chen-Guang
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin
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Shi Qi
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin
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LIANG Qian-Qian
Institute of Spine, Shanghai University of Traditional Chinese Medicine
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Cui Xue-jun
Institute Of Spine Shanghai University Of Traditional Chinese Medicine
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Hou Wei
Department Of Orthopaedics & Traumatology Longhua Hospital Shanghai University Of Traditional Ch
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Liang Qian-qian
Department Of Orthopaedics & Traumatology Longhua Hospital Shanghai University Of Traditional Ch
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Bian Qin
Department Of Orthopaedics & Traumatology Longhua Hospital Shanghai University Of Traditional Ch
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Xi Zhi-jie
Department Of Orthopaedics & Traumatology Longhua Hospital Shanghai University Of Traditional Ch
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Hou Wei
Department of Communication Engineering and Informatics, The University of Electro-Communications
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