Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

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概要

• 論文の詳細を見る

• Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II–collagen level, decreased type X–collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

• 社団法人 日本薬理学会の論文

著者

• Hou Wei

  Department of Hepatology, Capital University of Medical Science Affiliated Beijing You An Hospital

• WANG Yong-Jun

  Institute of Spine, ShangHai University of Traditional Chinese Medicine

• Liang Qian-Qian

  Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin

• Xi Zhi-Jie

  Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin

• Bian Qin

  Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin

• Cui Xue-Jun

  Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin

• Li Chen-Guang

  Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin

• Shi Qi

  Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chin

関連論文

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• Cervical Intervertebral Disc Degeneration Induced by Unbalanced Dynamic and Static Forces : A Novel In Vivo Rat Model
• Insulin-Like Growth Factor-1 Treatment Prevents Anti-Fas Antibody-Induced Apoptosis in Endplate Chondrocytes
• Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats
• A Continuous Observation of the Degenerative Process in the Intervertebral Disc of Smad3 Gene Knock-Out Mice
• Herb Formula "Fufangqishe-Pill" Prevents Upright Posture-Induced Intervertebral Disc Degeneration at the Lumbar in Rats
• Prolonged Upright Posture Induces Calcified Hypertrophy in the Cartilage End Plate in Rat Lumbar Spine

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