A Metagenomic Approach to the Identification of UDP-Glucose 4-Epimerase as a Menadione Resistance Protein
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概要
- 論文の詳細を見る
Quinones are potentially toxic agents that generate reactive oxygen species (ROS) upon reduction. We screened a metagenomic library for a menadione resistance gene to identify UDP-glucose 4-epimerase (UGE). Escherichia coli carrying the gene became resistant to various quinones, but not to ROS. Because UGE is involved in the biosynthesis of lipopolysaccharides, it may have contributed to forming a permeability barrier against lipophilic quinones.
- 社団法人 日本農芸化学会の論文
- 2008-06-23
著者
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Suenaga Hikaru
Institute For Biological Resources And Functions Aist
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Miyazaki Kentaro
Institute For Biological Resources And Functions Aist
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Miyazaki Kentaro
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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Suenaga Hikaru
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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Mori Toshio
Dep. Of Agro-environmental Sciences Fac. Of Agriculture Kyushu Univ.
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MORI Toshio
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science
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Mori Toshio
Department Of Agro-environmental Sciences Faculty Of Agriculture Kyushu University
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