Reduced Thymic Size and Numbers of Splenic CD4^+ and CD8^+ Cells in Artificially Reared Mouse Pups
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概要
- 論文の詳細を見る
The effect of early nutrition on the development of the immune tissue and T cells of mouse pups was examined. Newborn mice were divided into three experimental groups: mother-reared (MR) pups, pups that were fed on a milk substitute from the first day (AR-0), and the third day (AR-2), using a hand-feeding system. The average thymic size of the AR-2 pups was respectively significantly larger and smaller than that of the AR-0 and MR pups. In contrast, the splenic sizes of the AR-0 and AR-2 pups were greater than that of the MR pups. The numbers of CD4+CD8− and CD4−CD8+ cells in the spleen of the MR pups were significantly higher than those in the AR-0 pups. These results indicate that early nutrition affected the sizes of the thymus and spleen and the composition of CD4+CD8− or CD4−CD8+ T cells in the spleen.
- 社団法人 日本農芸化学会の論文
- 2007-10-23
著者
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Yajima Takaji
Food Function And Nutrition Science Institute Division Of Research And Development Meiji Dairies Cor
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Yajima Takaji
Food Science Institute Division Of Research And Development Meiji Dairies Corporation
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Yajima Masako
Department Of Lactic Acid Bacteria Food Science Institute Division Of Research And Development Meiji
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Terahara Masaki
Department Of Lactic Acid Bacteria Food Science Institute Division Of Research And Development Meiji
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HOSHIBA Junji
Department of Animal Resources, Advanced Science Research Center, Okayama University
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Hoshiba Junji
Department Of Animal Resources Advanced Science Research Center Okayama University
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Yajima Masako
Department Of Lactic Acid Bacteria Food Science Institute Division Of Research And Development Meiji
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Yajima Masako
Department of Chemistry, Faculty of Science, Tokai University
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