Lifestyle Modification in Metabolic Syndrome and Associated Changes in Plasma Amino Acid Profiles
スポンサーリンク
概要
- 論文の詳細を見る
Background: Although lifestyle modification is the key treatment of metabolic syndrome (MetS), clinical data on the dynamical relationship between metabolic state and MetS has been limited. This study investigated the mutual correlations between demographic and biochemical variables, and the metabolic state based on the plasma amino acid (AA) concentrations, during a lifestyle modification for MetS. Methods and Results: Japanese subjects, consisting of 54 patients with MetS [MetS(+)] and 35 persons without MetS [MetS(-)] were included in the study. Before a lifestyle modification program, the levels of glutamate metabolism-related AA (Glu-mAA), aromatic AA metabolism-related AA (Aromatic-mAA) and alanine metabolism-related AA (Ala-mAA) were significantly higher, while those of glycine-serine-threonine metabolism-related AA (Gly-Ser-Thr-mAA) were significantly lower compared to those in MetS(-). After a lifestyle modification, significant reductions (P<0.05) in the BMI (-1.4 kg/m2), mean blood pressure (-7.9 mmHg), hemoglobin A1c (-0.4%), and triglycerides (-30.6 mg/dl) were observed, and significant differences in the plasma AA levels between MetS(+) and MetS(-) were resolved. In addition, the diagnostic items of MetS were positively correlated with the levels of Glu-mAA, Ala-mAA, branched chain AA (BCAA)-mAA, Aromatic-mAA, and negatively correlated with the levels of Gly-Ser-Thr-mAA. Conclusions: As MetS subsided, the abnormality of mean plasma AA levels of the MetS(+) group returned to similar values as those in the MetS(-) group, suggesting a novel viewpoint regarding the metabolic mechanism of lifestyle modification. (Circ J 2010; 74: 2434-2440)
- 2010-10-25
著者
-
Tochikubo Osamu
Department Of Public Health Yokohama City University School Of Medicine
-
MIZUSHIMA Shunsaku
Department of Public Health, School of Medicine, Yokohama City University
-
Tochikubo Osamu
Department Of Preventive Medicine Yokohama City University Graduate School Of Medicine
-
NISHIJIMA Kiyoko
Department of Public Health, Yokohama City University School of Medicine
-
Ando Toshihiko
Institute Of Life Sciences Ajinomoto Company Inc
-
KAMAURA Mitsumasa
Department of Occupational Health, Kanagawa Health Service Association
-
TAKAHASHI Mitsuo
Institute of Life Sciences, Ajinomoto Company Inc
-
Mizushima Shunsaku
Department Of Public Health Yokohama City University School Of Medicine
-
Nishijima Kiyoko
Department Of Public Health Yokohama City University School Of Medicine
-
Kamaura Mitsumasa
Department Of Occupational Health Kanagawa Health Service Association
-
Takahashi Mitsuo
Institute Of Life Sciences Ajinomoto Company Inc
-
Mizushima Shunsaku
Department Of Epidemiology And Public Health Yokohama City University Graduate School Of Medicine
-
Tochikubo Osamu
Department Of Epidemiology And Public Health Yokohama City University Graduate School Of Medicine
-
NISHIJIMA Kiyoko
Department of Public Health, Yokohama City University, School of Medicine
-
TOCHIKUBO Osamu
Department of Epidemiology and Public Health, Yokohama City University, Graduate School of Medicine
-
MIZUSHIMA Shunsaku
Department of Epidemiology and Public Health, Yokohama City University, Graduate School of Medicine
関連論文
- Measurement of Hemodynamics During Postural Changes Using a New Wearable Cephalic Laser Blood Flowmeter
- Sexual Behaviour of Commercial Sex Workers and Their Clients in Cambodia
- Comparative Studies of Diet-Related Factors and Blood Pressure among Chinese and Japanese : Results from the China-Japan Cooperative Research of the WHO-CARDIAC Study
- Circadian Variation of Hemodynamics and Baroreflex Functions in Patients with Essential Hypertension
- Seasonal Influence on Blood Pressure in Elderly Normotensive Subjects
- Influence of Mental Stress on Cardiovascular Function as Evaluated by Changes in Energy Expenditure
- Relation between Sodium Intake and Blood Pressure during Sleep in Young Men
- Relation Between 24-h Heart Rate Variability and Blood Pressure Fluctuation During Exercise in Stroke Patients
- Estimation of Base Blood Pressure by Using a New Device in the Outpatient Clinic
- WILLINGNESS TO PAY FOR A PUBLIC HEALTH CHECKUP PROGRAM : ASSESSMENT BY THE TRAVEL COST METHOD
- Sodium Intake and Cardiac Sympatho-Vagal Balance in Young Men with High Blood Pressure
- A New Double Cuff Sphygmotonometer for Accurate Blood Pressure Measurement
- OE-319 Self-monitoring of Home Blood Pressure and Daily Salt Intake by Urine-Cup with Electrical Device(Hypertension, clinical-2 (H) OE54,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Pulse-Synchronized Massage With Air Cuffs on Peripheral Blood Flow and Autonomic Nervous System
- Relationship between salt intake and autonomic nervous system activity in young subjects
- Relationship between left ventricular hypertrohpy and insulin resistance in patients with essential hypertension
- Japanese Society of Hypertension (JSH) Guidelines for Self-Monitoring of Blood Pressure at Home
- Lifestyle Modification in Metabolic Syndrome and Associated Changes in Plasma Amino Acid Profiles
- Utility and feasibility of a new programmable home blood pressure monitoring device for the assessment of nighttime blood pressure
- Estimation of Myocardial Cell Damage on the Basis of Mean Electrocardiographic Voltage and Anatomical Left Ventricular Mass
- New Finger-Occlusion Plethysmograph for Estimating Peripheral Blood Flow and Vascular Resistance
- OJ-030 A New Finger-occlusion Plethysmography Method for Estimating Peripheral Blood Flow and Vascular Resistance(Peripheral circulation/Vascular disease-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Dietary Soybeans Intake and Bone Mineral Density among 995 Middle-Aged Women in Yokohama
- Weight Gain and Risk of Impaired Fasting Glucose After Smoking Cessation
- Stroke Prevention by Dietary Protein, Calcium (Ca) and Magnesium (Mg) Supplementation in Salt-Loaded Stroke-Prone SHR (SHRSP)
- Genetical involvement of urinary calcium excretion in response to pregnancy as a stress in rats