メロキシカムによる非小細胞肺癌の増殖抑制効果

概要

論文の詳細を見る
Cyclooxygenase(COX)-2 has been reported to play an important role in carcinogenesis. Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 expressing and COX-1 negative colorectal cancer cells. We evaluated the effects of meloxicam on the growth of lung cancer. By reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis, COX-2 but not COX-1 was expressed in human non-small cell lung cancer (NSCLC) cell lines (A549 and PC14). In human small cell lung cancer (SCLC) cell line (H841), both COX-1 and COX-2 were not detected. MTT assay and prostaglandin (PG) E2 enzyme immunoassay showed that meloxicam inhibited the growth and PGE2 production of both A549 and PC14 but not H841 cells. These findings suggest that COX-2 may play an important role in the pathogenesis and progression of NSCLC and that meloxicam may be a useful therapeutic agent in the treatment of NSCLC.
日本炎症・再生医学会の論文
2005-05-25