Sorafenib 投与後早期に代謝性脳症を併発し死亡した進行肝細胞癌の1例

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We experienced a case which was died of metabolic encephalopathy on the early course of oral treatment with sorafenib. The patient was 60s-year-old with advanced-stage of hepatocellular carcinoma. After 14 days of oral treatment with sorafenib, we found that the patient had disorientation and asterixis, which developed to deep coma, without serious hepatic failure. The patient died after 17 days of sorafenib treatment. We diagnosed as metabolic encephalopathy because he did not display obvious signs of hepatic failure. There was no factor which caused metabolic encephalopathy except for sorafenib administration. We have to consider the causal relationship between sorafenib administration and metabolic encephalopathy.
社団法人　日本肝臓学会の論文
2009-10-25