Interaction of ADIPOQ Genetic Polymorphism With Blood Pressure and Plasma Cholesterol Level on the Risk of Coronary Artery Disease
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概要
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Background: The protective effect of +45T >G polymorphism in the adiponectin gene (ADIPOQ) on coronary artery disease (CAD) has been demonstrated in European populations, so this study investigated the effect of +45T >G polymorphism on the risk of CAD and its interactions with other metabolic risk factors in a Chinese population. Methods and Results: The +45T >G polymorphism (rs2241766) of ADIPOQ was genotyped in 600 patients with angiographically diagnosed CAD and in 718 controls. The G allele at the +45T >G polymorphism was associated with a lower risk of CAD (odds ratio (OR), 0.76; 95% confidence interval (CI), 0.64-0.89; P=0.001). The protective effect of the G allele at +45T >G polymorphism was magnified at blood pressure <140/90 mmHg (OR, 0.65; 95%CI, 0.51-0.82; P=0.0004), but disappeared at blood pressure ≥140/90 mmHg (OR, 0.98; 95%CI, 0.76-1.28; P=0.93), indicating an interaction between +45T >G polymorphism and blood pressure on CAD risk (P=0.02 for interaction). A similar interaction was also observed between plasma cholesterol level and the +45T >G polymorphism. Conclusions: An association of ADIPOQ genetic polymorphism with CAD risk is modified by traditional risk factors, such as blood pressure and plasma cholesterol level. (Circ J 2009; 73: 1934-1938)
- 社団法人 日本循環器学会の論文
- 2009-09-20
著者
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LIEN Wen-Pin
Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan
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Lien Wen-pin
Department Of Internal Medicine National Taiwan University Hospital
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CHUANG Lee-Ming
Department of Internal Medicine, College of Medicine, National Taiwan University
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Jiang Yi-der
Department Of Internal Medicine National Taiwan University Hospital Yunlin Branch
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Jiang Yi-der
Department Of Internal Medicine National Taiwan University Hospital
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Jiang Ju-Ying
Department of Endocrinology, Far-Eastern Memorial Hospital
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Jiang Ju-ying
Department Of Internal Medicine Far Eastern Memorial Hospital
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Chuang Lee-ming
Department Of Internal Medicine National Taiwan University Hospital Yunlin Branch
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Chuang Lee-ming
Department Of Internal Medicine And Graduate Institute Of Clinical Medicine National Taiwan Universi
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HWANG Juey-Jen
Department of Internal Medicine, National Taiwan University Hospital
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Hwang Juey-jen
Department Of Internal Medicine National Taiwan University Hospital
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Hwang Juey-jen
Department Of Internal Medicine National Taiwan University Hospital Yunlin Branch
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CHIANG Fu-Tien
Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch
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Chiang Fu-tien
Department Of Internal Medicine National Taiwan University Hospital Yunlin Branch
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CHIANG Fu-Tien
Department of Internal Medicine
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CHANG Yi-Cheng
Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch
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