Myocardial Mechanics and Titin in Experimental Insulin-resistant Rats.

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概要

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• We investigated the intrinsic cardiac mechanics of myocardium and changes in titin in insulin-resistant rats. Microsonometry and micromanometry were used to evaluate the maximal elastance (Emax) and myocardial stiffness constant (Km) of the left ventricle, in addition to the traditional systolic and diastolic cardiac function, with an isolated working heart preparation. Thirty 150g Wistar rats were divided into three groups of 10. Group A was fed rat chow, while groups B and C were fed a 66% fructose diet for 7-8 months. Group C also received clonidine. Group B rats developed insulin resistance, as well as elevated plasma glucose and blood pressure. Group C rats also had insulin resistance and elevated plasma glucose, but not higher blood pressure. Group B rats had decreased Emax, decreased peak-dp/dt, prolonged Tau and increased Km compared to normal control rats. Group C rats, which mimicked the clinical condition of diabetic cardiomyopathy, maintained normal global left ventricular function as revealed by cardiac output, peak+dp/dt, peak-dp/dt and Tau of relaxation. However, they had a lower Emax slope (355±51 vs 535±56mmHg•mm than group A rats, p<0.05) and increased Km (81.6±9.9 vs 25.5±4.8 in group A, p<0.001), even though the extent of elevation of plasma glucose was only mild (71.3±2.0 to 108.9±4.4mg/dl, p<0.001). Their left ventricular mass, myocyte size, interstitial fibrosis and vascular picture did not change. However, the content of myocardial titin decreased significantly (intensity ratio of titin/actin was 0.23±0.01 and 0.29±0.02 in group C and group A rats respectively, p<0.05). These findings suggest that changes in titin play a role in the change in myocardial functional characteristics and may be one of the causes of diabetic cardiomyopathy.

• International Heart Journal刊行会の論文

著者

• Wang Seu-mei

  Department Of Anatomy And Cell Biology College Of Medicine National Taiwan University

• Tsai Chang-her

  Department Of Surgery Internal Medicine And Pathology National Taiwan University Hospital

• TSENG Yung-Zu

  Department of Internal Medicine, College of Medicine, National Taiwan University

• CHIANG Fu-Tien

  Department of Internal Medicine

• Lo Huey-Ming

  Department of Internal Medicine

• TSENG Chuen-Den

  Department of Internal Medicine

• TSAI Chang-Her

  Departments of Surgery, College of Medicine, National Taiwan University

• HSU Kwan-Lih

  Department of Internal Medicine

• HSU Kwan-Lih

  Departments of Internal Medicine, College of Medicine, National Taiwan University

• CHEN Chaw-Fong

  Departments of Physiology, College of Medicine, National Taiwan University

• Tseng Yung-Zu

  Department of Cardiology, Show-Chwan Memorial Hospital

• WANG Seu-Mei

  Departments of Anatomy, College of Medicine, National Taiwan University

• TSENG Yung-Zu

  Departments of Internal Medicine, College of Medicine, National Taiwan University

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