Elevated Arterial Stiffness Evaluated by Brachial-Ankle Pulse Wave Velocity is Deleterious for the Prognosis of Patients With Heart Failure
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概要
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Background: Arterial stiffness is used as an index of arteriosclerosis. The goal of this study was to clarify whether increased arterial stiffness, evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), is a risk factor for the prognosis of heart failure (HF) patients. Methods and Results: After examination of the baPWV, as well as the levels of neurohumoral factors, the 72 enrolled HF patients were followed up for a survival study, which had a primary endpoint of re-admission because of HF. The secondary endpoint was cardiac death. Results of Cox proportional hazards modeling revealed that baPWV, systolic blood pressure (BP) and brain natriuretic peptide level were factors that affected survival (P<0.05). The patients were divided into 2 groups according to the cutoff baPWV value (1,750 cm/s). Although hemodynamic factors were similar between the groups, the high-baPWV group had a lower event-free survival rate for the primary and secondary endpoints than the low-baPWV group (P<0.05). BP at re-admission was higher in the high-baPWV group (174 ±30 mmHg) than in the low-baPWV group (121 ±33 mmHg, P<0.01). Conclusions: Elevated arterial stiffness is a risk factor for re-admission or cardiac death of HF patients. (Circ J 2009; 73: 673 - 680)
- 2009-03-20
著者
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ODA Yutaka
Department of Dental Materials Science, Tokyo Dental College
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MEGURO Tomomi
Department of Medicine, Tokyo Electric Power Company Hospital
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NAGATOMO Yuji
Department of Cardiovascular Medicine, Inagi Municipal Hospital
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NAGAE Atsushi
Department of Cardiovascular Medicine, Inagi Municipal Hospital
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SEKI Chiori
Department of Cardiovascular Medicine, Inagi Municipal Hospital
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KONDOU Nobusuke
Department of Cardiovascular Medicine, Inagi Municipal Hospital
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SHIBATA Masaru
Department of Cardiovascular Medicine, Inagi Municipal Hospital
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Meguro Tomomi
Department Of Medicine Tokyo Electric Power Company Hospital
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Nagatomo Yuji
Department Of Cardiovascular Medicine Inagi Municipal Hospital
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Oda Yutaka
Department Of Cardiovascular Medicine Inagi Municipal Hospital
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Seki Chiori
Department Of Cardiovascular Medicine Inagi Municipal Hospital
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Nagae Atsushi
Department Of Cardiovascular Medicine Inagi Municipal Hospital
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Oda Yutaka
Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medicine Osaka City Univ
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Kondou Nobusuke
Department Of Cardiovascular Medicine Inagi Municipal Hospital
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Shibata Masaru
Department Of Cardiovascular Medicine Inagi Municipal Hospital
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Shibata Masaru
Department Of Agricultural Chemistry Kyoto University:(present)asahi Kasei Chemicals Industry Co. Lt
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Nagatomo Yuji
Department Of Cardiology Keio University School Of Medicine
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