Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects
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概要
- 論文の詳細を見る
β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left side of the graft materials in the bone defects, platelet-rich plasma (PRP) was added. The rats were sacrificed at one, three, and five weeks. Bone formation rate (BFR), remaining β-TCP rate (RTR), β-TCP absorption rate (TAR), whole amount of β-TCP (WTCP), and total rate of BFR and RTR (TBR) were measured. Combined showed equivalent BFR to Allograft at five weeks, and showed higher RTR at one week and higher BFR at five weeks than TCP. Combined with PRP showed higher TAR than that without PRP at three weeks. Therefore, combination with allogenic bone showed reduced β-TCP absorption, hence enhancing the role of β-TCP in bone regeneration. These findings suggested that β-TCP is a better scaffold for bone regeneration if its early absorption is reduced when used in combination with an osteogenic material.
- 日本歯科理工学会の論文
- 2009-03-01
著者
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藤内 祝
横浜市立大学大学院医学研究科顎顔面口腔機能制御学
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MATSUI Yoshiro
Department of Cardiovascular Surgery, Hokkaido University Hospital
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Tohnai I
横浜市立大学 大学院医学研究科顎顔面口腔機能制御学講座
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Fukui T
St Luke's International Hospital
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Adachi Makoto
Department Of Dermatology Kanto Rosai Hospital
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Adachi Makoto
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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TOHNAI Iwai
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
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Fukui Takafumi
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
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Tohnai Iwai
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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Fukui Takafumi
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Fukui Takafumi
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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Mastui Yoshiro
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Matsui Yoshiro
Department Of Cardiac Surgery Hokkaido University Hospital
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HIROTA Makoto
Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine
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MIZUKI Nobuyuki
Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine
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WATANUKI Kei
Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine
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OZAWA Tomomichi
Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine
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IWAI Toshinori
Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine
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KISHI Teruki
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
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SHOJI Shihomi
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
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MONDEN Yuka
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
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Monden Yuka
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Kishi Teruki
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Shoji Shihomi
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Hirota Makoto
Department Of Oral And Maxillofacial Surgery Yokohama City University Hospital
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