Antihypertensive Effects of Nicotianamine from Soybean Broth in Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
The effect of the ACE inhibitor nicotianamine (NA), from soybean broth (SB), on blood pressure was investigated in spontaneously hypertensive rats (SHR) upon single and long-term administration. The IC50 value of NA from SB was 0.69 μmol/L. Single oral dose of NA (0.9 mg, 4.5 mg and 9.0 mg/kg body weight) decreased blood pressure 1 h after administration, and blood pressure returned to the control level 3 h after administration. Long-term oral dose of NA (0.9 mg and 4.5 mg/kg body weight) decreased blood pressure for 4 weeks after administration, while that of NA (9.0 mg/kg body weight) was decreased for the full 8-weeks feeding period. At 8 weeks after administration, serum NA content in SHR was determined by amino acid analyzer and revealed that NA was not detected in the blood of SHR (0.9 mg and 4.5 mg/kg body weight group), while 32.6 ± 7.3 μg/dL NA was detected in the 9.0 mg/kg body weight group. It was suggested that NA absorbed from the intestine decreased the systolic blood pressure (SBP) in SHR, and an appropriate NA level (9.0 mg/kg body weight group) may provide long-term antihypertensive effects upon administration.
- 2009-09-01
著者
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FURUSHO TADASU
Department of Nutrition, Jr College of Tokyo University of Agriculture
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Furusho Tadasu
Department Of Nutrition Jr. College Of Tokyo University Of Agriculture
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Furusho Tadasu
Department Of Nutrition Jr College Of Tokyo University Of Agriculture
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TAKENAKA Tetsuo
Faculty of Agriculture, Tamagawa University
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MURAYAMA Takashi
Faculty of Agriculture, Tamagawa University
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TAKENAKA Yoko
T&T Food Institute
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Takenaka Yoko
T&t Food Institute
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Takenaka Tetsuo
Faculty Of Agriculture Tamagawa University
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Murayama Takashi
Faculty Of Agriculture Tamagawa University
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FURUSHO Tadasu
Department of Agricultural Chemsitry, Faculty of Agriculture, Tokyo University of Agriculture
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