Vitamin D Receptor Polymorphism among Rickets Children in Mongolia
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概要
- 論文の詳細を見る
BACKGROUND: It was reported that 32% of children under five years old in Mongolia had symptoms of rickets. Vitamin D receptor (VDR) gene polymorphism has received attention in relation to bone metabolism. We therefore investigated whether VDR polymorphism is related to high prevalence of rickets in Mongolia and to bone properties in childhood.METHODS: We conducted a case-control study in Ulaanbaatar involving 80 children aged 7-10 years with a history of rickets (cases) and 72 children with no history of rickets (controls). VDR polymorphism was assessed using BsmI, ApaI, and TaqI, and bone properties were determined by measuring agestandardized midtibial cortical speed of sound (TCSOS).FINDINGS: Each allelic frequency was verified to satisfy the Hardy-Weinberg equilibrium in cases, controls, and the total sample. The VDR polymorphisms among cases (BB 3%, Bb 18%, bb 80%; AA 15%, Aa 38%, aa 47%; and TT 81%, Tt 17%, tt 3%) did not differ significantly from those among controls (BB 1%, Bb 13%, bb 86%; AA 16%, Aa 46%, aa 38%; and TT 86%, Tt 13%, tt 1%). There were no significant differences in TCSOS according to the VDR genotype among either cases or controls.CONCLUSIONS: The VDR polymorphism does not play a major role in the development of rickets in Mongolia and has no effect on TCSOS in childhood.J Epidemiol 2007; 17: 25-29.
- 日本疫学会の論文
- 2007-01-01
著者
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Urnaa Vaanchig
Health Promotion Division Of Public Health Graduate School Of Tokyo Medical And Dental University
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SEINO Kaoruko
International Health, Division of Public Health, Graduate School of Tokyo Medical and Dental Univers
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TAKANO Takehito
Health Promotion, Division of Public Health, Graduate School of Tokyo Medical and Dental University
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INOSE Tomoko
Health Promotion, Division of Public Health, Graduate School of Tokyo Medical and Dental University
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NAKAMURA Keiko
International Health, Division of Public Health, Graduate School of Tokyo Medical and Dental Univers
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KIZUKI Masashi
Health Promotion, Division of Public Health, Graduate School of Tokyo Medical and Dental University
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KANEKO Akie
Health Promotion, Division of Public Health, Graduate School of Tokyo Medical and Dental University
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Kaneko Akie
Health Promotion Division Of Public Health Graduate School Of Tokyo Medical And Dental University
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Nakamura K
International Health Graduate School Of Tokyo Medical And Dental University
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Inose Tomoko
Health Promotion Graduate School Of Tokyo Medical And Dental University
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Seino Kaoruko
International Health Graduate School Of Tokyo Medical And Dental University
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Kizuki Masashi
Health Promotion Division Of Public Health Graduate School Of Tokyo Medical And Dental University
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Takano T
Health Promotion Graduate School Of Tokyo Medical And Dental University
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Takano Takehito
Health Promotion Division Of Public Health Graduate School Of Tokyo Medical And Dental University
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Nakamura Keiko
International Health Division Of Public Health Graduate School Of Tokyo Medical And Dental Universit
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