Caveolae-Independent Activation of Protein Kinase A in Rat Neonatal Myocytes
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概要
- 論文の詳細を見る
Cardiomyocytes express both β1- and β2-adrenergic receptors, and these receptors play a differential role in chronotropic and inotropic effects of the heart. Caveolae are known as an important regulator of G-protein-coupled receptor signaling. In the present report, we examined whether caveolae have a role in β-adrenergic receptor-stimulated cAMP production and protein kinase A activation in neonatal myocytes. Isoproterenol-stimulated cAMP production was mediated by β1- and β2-subtypes, which depends on the receptor number of each subtype. However, protein kinase A activation was exclusively mediated by the β1-subtype. Disruption of caveolae by methyl-β-cyclodextrin treatment did not affect the relative contribution of subtypes to isoproterenol-stimulated cAMP production. β1-Subtype-mediated protein kinase A activation was also not affected by the disruption of caveolae. These results suggest that β1-adrenergic receptor-mediated protein kinase A activation is compartmentalized and independent of caveolae.
- 社団法人 日本薬理学会の論文
- 2005-06-20
著者
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Kobayashi Hiroyuki
Department Of Applied Chemistry Saitama University
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Kurose Hitoshi
Department Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences Kyushu Universi
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Nishida Motohiro
Department Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences Kyushu Universi
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FUKUTOMI Masashi
Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu Univer
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MARUYAMA Yoshiko
Laboratory of Cellular Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo
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Kurose Hitoshi
Department Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences Kyushu Universi
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Maruyama Yoshiko
Laboratory Of Cellular Signaling Graduate School Of Pharmaceutical Sciences University Of Tokyo
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Fukutomi Masashi
Department Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences Kyushu Universi
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Nishida Motohiro
Department Of Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Kyushu University
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Kurose Hitoshi
Department Of Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Kyushu University
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Kobayashi Hiroyuki
Department Of Anesthesiology Okayama Red Cross Hospital
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