アルコール摂取時の重心動揺における決定論性の評価

概要

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Equilibrium function in the cerebellum (vestibulo-cerebellar system) is deteriorated by medicinal actions (MAs). In the Romberg posture, the center of gravity, which was measured every 50 msec by stabilometry, appeared to shift with alcohol ingestion. In the previous study, a locus in the center of gravity (statokinesigram) was converted to a value of statistical indices such as area of sway, total locus length, and locus length per unit area, although these indices could not always distinguish between the statokinesigrams sampled from 7 healthy young males presenting with and without MAs. This measurement was made with an AMTI force plate. In this study, a statistical index “translation error” was estimated in a d-dimensional embedding space in order to compare statokinesigrams recorded before and after the ingestion of doubly diluted brandy in 30 s (1≤d≤10). We succeeded in validating a stochastic differential equation as a mathematical model of the body sway. The randomness in the model was preserved after alcohol intake and significantly increased in the medial/lateral direction. Visual information referred by the control system of standing posture might be regarded as an external forcing associated with the MA. This method is considered to be useful to diagnose the disorders of the vestibulo-cerebellar system.
日本めまい平衡医学会の論文
2007-02-01