LEXFおよびFXLE組み換え近交系を用いたディエティルベステロールの睾丸、下垂体重量減を決定する量的形質遺伝子の解析
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概要
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Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.
- 2006-04-01
著者
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日合 弘
Department of Pathology
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Hiai Hiroshi
Department Of Pathology And Biology Of Diseases Graduate School Of Medicine Kyoto University
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Hiai Hiroshi
Department Of Pathology And Biology Of Diseases Kyoto University Graduate School Of Medicine
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Hiai Hiroshi
Department Of Medical Chemistry And Molecular Biology Kyoto University Graduate School Of Medicine
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Tachibana Masayoshi
Saitama Cancer Center
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LU Lingmin
Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine
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TAMURA Atsushi
Saitama Cancer Center
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MATSUSHIMA Yoshibumi
Saitama Cancer Center
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SHISA Hayase
Saitama Cancer Center
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Lu Lingmin
Department Of Pathology And Biology Of Diseases Kyoto University Graduate School Of Medicine
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Matsushima Yoshibumi
埼玉県立がんセンター臨床腫瘍研究所
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橘 正芳
Saitama Cancer Center
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路 霊敏
Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine
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HIAI Hiroshi
Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine
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