Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives : the Structure Activity Relationship(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• Mangiferin, 2-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxy-9H-xanthen-9-one, obtained directly from methanolic extracts of Bombax ceiba leaves in substantial amounts demonstrated strong antioxidant activity (EC_<50> 5.8±0.96μg/ml or 13.74 μM) using DPPH assay comparable to rutin, commonly used as antioxidant for medical purposes. The acetyl and cinnamoyl derivatives were found to be less active than mangiferin whereas, methyl and 3, 6, 7-trimethylether tetraacetate derivatives were inactive implying that for antioxidant activity, free hydroxyl groups and catechol moiety are essential. Moreover, mangiferin showed hepatoprotective activity against carbon tetrachloride induced liver injury further supporting the free radical scavenging property in the in vivo system. Additionally, plant extracts and mangiferin failed to exhibit acute anti-inflammatory activity whereas, it displayed significant analgesic effect in acetic acid-induced writhing and hot plate tests in mice. Using naloxone, it was revealed that plant extracts induced analgesia was independent of opioid receptor, whereas, mangiferin demonstrated significant interaction with it at peripheral site with a slight contribution at the neuronal level.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• ALI Muhammad

  H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences Un

• Ali Muhammad

  H.e.j. Research Institute Of Chemistry International Center For Chemical And Biological Sciences Uni

• Ali Muhammad

  Hmi Institute Of Pharmacology And Herbal Sciences Hamdard University

• Faizi Shaheen

  Hej Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi

• Faizi S

  Hej Research Institute Of Chemistry International Center For Chemical Sciences University Of Karachi

• Ahmed M

  Hmi Institute Of Pharmacology & Herbal Sciences Hamdard University

• Zikrurrehman Sadia

  Hej Research Institute Of Chemistry University Of Karachi

• DAR Ahsana

  H.E.J. Research Institute of Chemistry, University of Karachi

• FAIZI Shaheen

  H.E.J. Research Institute of Chemistry, University of Karachi

• NAQVI Sabira

  H.E.J. Research Institute of Chemistry, University of Karachi

• ROOME Talat

  H.E.J. Research Institute of Chemistry, University of Karachi

• ZIKRURREHMAN Sadia

  H.E.J. Research Institute of Chemistry, University of Karachi

• FIRDOUS Sadiqa

  Department of Chemistry, University of Karachi

• MOIN Syed

  Department of Chemistry, University of Karachi

• Moin Syed

  Department Of Chemistry University Of Karachi

• Dar Ahsana

  H.e.j. Research Institute Of Chemistry University Of Karachi

• Roome Talat

  H.e.j. Research Institute Of Chemistry University Of Karachi

• Naqvi Sabira

  H.e.j. Research Institute Of Chemistry University Of Karachi

• Firdous Sadiqa

  Department Of Chemistry University Of Karachi

• Ali Muhammad

  H.e.j Research Institute Of Chemistry University Of Karachi

関連論文

• Hypotensive Activity and Toxicology of Constituents from Bombax ceiba Stem Bark(Pharmacology)
• α-Glucosidase Inhibitors Ellagic Acid Derivatives with Immunoinhibitory Properties from Terminalia superba
• α-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)
• Hypotensive Activity, Toxicology and Histopathology of Opuntioside-I and Methanolic Extract of Opuntia dillenii(Pharmacology)
• Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives : the Structure Activity Relationship(Pharmacology)
• Garcintin : A new flavonol glycoside from Lotus garcinii(Fabaceae)

スポンサーリンク