Hypotensive Activity, Toxicology and Histopathology of Opuntioside-I and Methanolic Extract of Opuntia dillenii(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Methanolic extract of Opuntia dillenii cladodes and its pure compound α-pyrone glycoside, opuntioside-I showed potent hypotensive activity in normotensive rats. Both the extract and opuntioside-I showed comparable effect of 44-54% fall in Mean Arterial Blood Pressure (MABP) at the dose of 10mg/kg. No mortality was observed in rats even at the doses of 1000mg/kg/d and 900mg/kg/d per oral of extract and opuntioside-I respectively. However, histopathology revealed adverse effects of high doses on liver and spleen of the experimental animals.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
-
AHMAD Syed
HMI Institute of Pharmacology and Herbal Sciences, Hamdard University
-
FAIZI Shaheen
HEJ Research Institute of Chemistry, University of Karachi
-
Ahmad Syed
Hmi Institute Of Pharmacology & Herbal Sciences Hamdard University
-
Faizi Zareen
Batool General Hospital
-
Ali Muhammad
Hmi Institute Of Pharmacology And Herbal Sciences Hamdard University
-
Faizi Shaheen
Hej Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi
-
Faizi S
Hej Research Institute Of Chemistry International Center For Chemical Sciences University Of Karachi
-
Saleem Rubeena
Faculty Of Pharmacy Hamdard University:hmi Institute Of Pharmacology & Herbal Sciences Hamdard U
-
Ahmed M
Hmi Institute Of Pharmacology & Herbal Sciences Hamdard University
-
AHMAD Mohammad
HMI Institute of Pharmacology & Herbal Sciences, Hamdard University
-
AZMAT Aisha
HMI Institute of Pharmacology & Herbal Sciences, Hamdard University
-
ABIDI Lubna
HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karac
-
Abidi Lubna
Hej Research Institute Of Chemistry International Center For Chemical Sciences University Of Karachi
-
Azmat Aisha
Hmi Institute Of Pharmacology & Herbal Sciences Hamdard University
関連論文
- Hypotensive Activity and Toxicology of Constituents from Bombax ceiba Stem Bark(Pharmacology)
- Hypotensive Activity, Toxicology and Histopathology of Opuntioside-I and Methanolic Extract of Opuntia dillenii(Pharmacology)
- Analgesic and Antioxidant Activity of Mangiferin and Its Derivatives : the Structure Activity Relationship(Pharmacology)