Antioxidant Effects of Aqueous Extracts from Dried Calyx of Hibiscus sabdariffa LINN. (Roselle) in Vitro Using Rat Low-Density Lipoprotein (LDL)(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu^<2+>-mediated oxidation of LDL (p<0.05) in vitro. The inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 μM of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
-
SATO Hitoshi
Department of Clinical and Molecular Pharmacokinetics/Pharmacodynamics, School of Pharmaceutical Sci
-
Hirunpanich Vilasinee
Department Of Pharmacology Faculty Of Pharmacy Mahidol University
-
UTAIPAT Anocha
Department of Pharmacology, Faculty of Pharmacy, Mahidol University
-
MORALES Noppawan
Department of Pharmacology, Faculty of Science, Mahidol University
-
BUNYAPRAPHATSARA Nuntavan
Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University
-
HERUNSALEE Angkana
Pharmacodynamics, Faculty of Pharmaceutical Science, Showa University
-
SUTHISISANG Chuthamanee
Medicinal Plant Research Institute Department of Medical Sciences, Ministry of Public Health
-
Sato Hitoshi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Herunsalee Angkana
Pharmacodynamics Faculty Of Pharmaceutical Science Showa University
-
Utaipat Anocha
Department Of Pharmacology Faculty Of Pharmacy Mahidol University
-
Morales Noppawan
Department Of Pharmacology Faculty Of Science Mahidol University
-
Suthisisang Chuthamanee
Medicinal Plant Research Institute Department Of Medical Sciences Ministry Of Public Health
-
Bunyapraphatsara Nuntavan
Department Of Pharmacognosy Faculty Of Pharmacy Mahidol University
-
Sato Hitoshi
Department Of Clinical And Molecular Pharmacokinetics
-
Sato Hitoshi
Department Of Cardiology Juntendo University School Of Medicine
-
Uraipat Anocha
Department of Pharmacology, Faculty of Pharmacy, Mahidol University
-
SATO Hitoshi
Department of Clinical and Molecular Pharmacokinetics/Pharmacodynamics, Faculty of Pharmaceutical Science, Showa University
-
SATO Hitoshi
Department of Animal Science, Faculty of Agriculture, Tohoku University
関連論文
- Estimating Pediatric Doses of Drugs Metabolized by Cytochrome P450 (CYP) Isozymes, Based on Physiological Liver Development and Serum Protein Levels
- Intercomparison of Luminescence Measurements of Bricks from Dolon' Village : Experimental Methodology and Results from Japanese Laboratory
- Association of Seropositivity for Antibody to Chlamydia-Specific Lipopolysaccharide and Coronary Artery Disease in Japanese Men
- Preventing Angiographic Progression of Coronary Atherosclerosis with Pravastatin
- Inhibitory Effect of Azole Antifungal Agents on the Glucuronidation of Lorazepam Using Rabbit Liver Microsomes in Vitro
- First Observation of a Wooden Foreign Body in Soft Palate by Means of Synchrotron X-Ray Refraction Contrast
- Population pharmacokinetics of docetaxel in patients with hepatic dysfunction treated in an oncology practice
- Population pharmacokinetic and pharmacodynamic analysis for time courses of docetaxel-induced neutropenia in Japanese cancer patients
- Effect of Noise on the Low Flow Rate Chaos in the Belousov-Zhabotinsky Reaction
- Inhibitory Effects of Saturated and Polyunsaturated Fatty Acids on the Cytochrome P450 3A Activity in Rat Liver Microsomes(Biopharmacy)
- Antioxidant Effects of Aqueous Extracts from Dried Calyx of Hibiscus sabdariffa LINN. (Roselle) in Vitro Using Rat Low-Density Lipoprotein (LDL)(Pharmacology)
- Structure, Composition, and Vibrational Property of Iodine-Doped Polyvinyl Alcohol Studied by Temperature-Dependent I K-Edge Extended X-Ray-Absorption Fine Structure
- Local Structures of RbBr_xCl_ and CuBr_xCl_ Solid Solutions Studied by Temperature-Dependent Br K-Edge Extended X-Ray-Absorption Fine-Structure Spectroscopy
- Projections from the nucleus reticularis magnocellularis to the rat cervical cord using electrical stimulation and iontophoretic injection methods
- Resonant Photoemission Spectroscopy in the Mn 2p-3d Excitation Region of NiAs-Type MnTe
- Characterization of acyclovir susceptibility and genetic stability of varicella-zoster viruses isolated during acyclovir therapy
- The Effects of Indirect Treatment of Proprioceptive Neuromuscular Facilitation
- Pharmacokinetic Study of Taxol-Loaded Poly(lactic-co-glycolic acid) Microspheres Containing Isopropyl Myristate after Targeted Delivery to the Lung in Mice
- Preparation and Characterization of Poly(lactic-co-glycolic acid)Microspheres for Targeted Delivery of a Novel Anticancer Agent, Taxol
- In Vitro and In Vivo Evaluation of Chitosan Microspheres Containing Cisplatin : Hepatic Artery Chemo-embolization in Dogs
- Herpes simplex virus-induced, death receptor-dependent apoptosis and regression of transplanted human cancers
- Pharmacokinetic and Pharmacodynamic Analysis of the Antihypercalcemic Effect of Incadronate Disodium in Rats
- Determination of' the Lowest Unoccupied Orbital in the Layered Perovskite LaSrMnO_4 Using Polarized Oxygen K Edge Absorption Spectroscopy : Condensed Matter: Electronic Properties, etc.
- Characterization of Pak-Bung Green Hairy Roots Cultivated under Light Irradiation
- High variability of albuminuria in nondiabetic population : the Takahata Study
- Correlation between Neurotoxic Events and Intracerebral Concentration of Tacrolimus in Rats
- Pharmacokinetic/Pharmacodynamic Analysis of Tacrolimus-Induced QT Prolongation in Guinea Pigs
- Antipyretic Activity of Gingyo-san, a Traditional Medicine, in Influenza Virus-Infected Mice
- Efficacy of Cafon gel on cutaneous infection with herpes simplex virus (HSV)-2 and acyclovir-resistant HSV in mice
- Pharmacokinetics of a Chinese Traditional Medicine, Denshensu (3,4-Dihydroxyphenyllactic Acid), in Rabbits Using High-Performance Liquid Chromatography
- Rectal Absorption of Ozagrel from a Suppository Containing Its Commercial Tablet in Health Human Subjects
- Rectal Absorption of a New Thromboxane Synthetase Inhibitor, DP-1904, from Witepsol Suppositories in Rabbits
- Pharmacokinetic and Pharmacodynamic Modeling of a Thromboxane Synthetase Inhibitor, Ozagrel, in Human
- Pharmacokinetic and Pharmacodynamic Modeling of a Novel Thromboxane Synthetase Inhibitor, DP-1904, in Human
- Antiepileptic Effects of Tiagabine, a Selective GABA Uptake Inhibitor, in the Rat Kindling Model of Temporal Lobe Epilepsy
- Comparative Antioxidant Activities of Curcumin and Its Demethoxy and Hydrogenated Derivatives(Pharmacology)
- Hepatocyte Injury by non-hepatitis viruses in vitro
- Microdialysis Assessment of Fibrin Glue Containing Sodium Alginate for Local Delivery of Doxorubicin in Tumor-Bearing Rats
- Disposition of Liposomal Cepharanthine after Intraperitoneal Administration in Mice
- Microdialysis Assessment of Microfibrous Collagen Containing Sodium Alginate for Local Delivery of Amikacin
- Rectal Absorption of a 5-HT_3 Receptor Antagonist, Ondansetron, from a Suppository Containing a Tablet in Rabbits
- Magnetic Targeting of Thermosensitive Magnetoliposomes to Mouse Livers: An In Situ On-line Perfusion System.
- Lectin Histochemistry on Esophageal Mucosa of Pigs
- The Actual State of Proprioceptive Neuromuscular Facilitation Education in Physical Therapy Schools in Japan
- Comparison of Physicians' Compliance, Clinical Efficacy, and Drug Cost before and after Introduction of Asthma Prevention and Management Guidelines in Japan (JGL2003)
- Two Different Functions in the Masticatory Muscles during Voluntary Clenching Performances
- Hepatic Reduction of Carbamoyl-PROXYL in Ferric Nitrilotriacetate Induced Iron Overloaded Mice: An in Vivo ESR Study
- Continuous Production of β-D-Fructofuranosyl-(2→1)-2-acetamido-2-deoxy-α-D-glucopyranoside (N-Acetylsucrosamine) Using a Column Reactor Packed with β-Fructofuranosidase-containing Mycelia of Aspergillus oryzae Immobilized on a Porous Carrier
- Social Skills Training for Children
- Protective Effects of KW-3902, an Adenosine A1-Receptor Antagonist, Against the Nephropathy Induced by Repeated Administration of Cisplatin in Rats.
- Effect of Probucol on Neointimal Thickening in a Stent Porcine Restenosis Model
- Protective Effects of KW-3902, an Adenosine A1-Receptor Antagonist, Against Cisplatin-Induced Apoptosis in Rat Kidney.
- Long-term outcomes of women with coronary artery disease following complete coronary revascularization