Quantitative Determination of Four Diterpenoids in Radix Salviae Miltiorrhizae Using LC-MS-MS
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概要
- 論文の詳細を見る
An HPLC-ESI-MS-MS method has been developed for the quantitative determination of four diterpenoids, dihydrotanshinone I, cryptotanshinone, tanshinone I, and tanshinone IIA in Radix Salviae Miltiorrhizae (RSM, the root of Salvia miltiorrhiza BGE.). The diterpenoids were chromatographically separated on a C18 HPLC column, and the quantification of these diterpenoids was based on the fragments of [M+H]^+ under collision-activated conditions and in Selected Reaction Monitioring (SRM) mode. The quantitative method was validated, and the mean recovery rates from fortified samples (n=5) of dihydrotanshinone I, cryptotanshinone, tanshinone I, and tanshinone IIA were 95.0%, 97.2%, 93.1%, and 95.9% with variation coefficient of 6.0%, 4.3%, 3.7%, and 4.2%, respectively. The established method was successfully applied to the quality assessment of seven batches of RSM samples collected from different regions of China.
- 公益社団法人日本薬学会の論文
- 2005-06-01
著者
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Jiang Zhi
School Of Chinese Medicine Hong Kong Baptist University
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Jiang Zhi‐hong
Hong Kong Baptist Univ. Hkg
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Hu Ping
Hong Kong Baptist Univ. Hkg
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Hu Ping
School Of Agriculture And Biology Shanghai Jiaotong University
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Luo Guo‐an
East China Univ. Sci. And Technol. Shanghai Chn
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Luo Guo
School Of Chemistry And Pharmaceutics East China University Of Science And Technology:analysis Cente
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Zhao Zhong
School Of Chinese Medicine Hong Kong Baptist University
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LUO Guo-An
School of Pharmaceutics, East-China University of Science & Technology
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Jiang Zhi
School Of Chinese Medicine Hong Kong Baptist Univ.
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Zhao Zhong-zhen
School Of Chinese Medicine Hong Kong Baptist Univ.
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Luo Guo-An
School of Chemistry and Pharmaceutics, East China University of Science and Technology:Analysis Center, Tsinghua University
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