Morning Glory Sign : A Particular MR Finding in Progressive Supranuclear Palsy
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概要
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Background and Purpose: We have encountered a peculiar atrophic change in the midbrain in some patients with parkinsonian syndromes. We discovered these patients had vertical supranuclear gaze-palsy, an eye movement disorder. The purpose of this study was to elucidate whether this atrophic pattern of the midbrain (which we have termed morning glory sign) is related to the vertical eye movement disorder, in particular to progressive supranuclear palsy (PSP). Methods: We reviewed T2-weighted axial images obtained from 42 patients with parkinsonian syndromes, including five patients with PSP, 23 patients with Parkinsons disease, and 14 patients with multiple system atrophy (MSA). We focused on a specific atrophy of the midbrain, the morning glory sign, which is a concavity of the lateral margin of the tegmentum of the midbrain. Results: The morning glory sign was detected in four of the five patients with PSP and in one (striatonigral degeneration; SND) of the14 patients with MSA. All morning glory sign patients had vertical supranuclear gaze-palsy, as did the one PSP patient without the morning glory sign. Vertical supranuclear gaze-palsy was seen in no other patients (23 patients with Parkinsons disease and 13 patients with MSA) who lacked the morning glory sign. Conclusions: Morphologically, the morning glory sign is believed to be related to vertical supranuclear gaze-palsy. This sign should be considered a useful clue when diagnosing PSP.
- 日本磁気共鳴医学会の論文
- 2004-10-15
著者
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細矢 貴亮
山形大学医学部放射線診療科
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細矢 貴亮
国立病院四国がんセンター 放射線科
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細矢 貴亮
山形大 医 放射線科
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細矢 貴亮
山形大学医学部
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細矢 貴亮
山形大学
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細矢 貴亮
山形大学 医学部第三内科
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KAWANAMI Toru
Third Department of Intenal Medicine, Yamagata University School of Medicine
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SUGAI YUKIO
Department of Radiology, Yamagata University School of Medicine
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HOSOYA Takaaki
Department of Radiology, Yamagata University School of Medicine
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ADACHI Michito
Department of Radiology, Ohshima Clinic
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OHSHIMA Humi
Department of Neurology, Ohshima Clinic
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菅井 幸雄
山形大学医学部放射線科
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細矢 貴亮
Department Of Radiology Yamagata University School Of Medicine
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Hosoya Takaaki
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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菅井 幸雄
Department Of Radiology Yamagata University School Of Medicine
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Sugai Yukio
Department Of Radiology Yamagata University Faculty Of Medicine
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Sugai Yukio
Department Of Radiology Yamagata University School Of Medicine
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Ohshima Humi
Department Of Neurology Ohshima Clinic
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Kawanami Toru
Third Department Of Internal Medicine Yamagata University School Of Medicine
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安達 真人
Department Of Radiology Ohshima Clinic
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Adachi Michito
Department Of Radiology Ohshima Clinic
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Hosoya Takaaki
Department of Biomolecular Functional Engineering, Ibaraki University, Hitachi, Ibaraki 316-8511, Japan
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