Exacerbation of Chronic Inflammatory Demyelinating Polyradiculoneuropathy during Interferonβ-1b Therapy in a Patient with Childhood-onset Multiple Sclerosis
スポンサーリンク
概要
- 論文の詳細を見る
Interferonβ-1b (IFNβ-1b) is commonly used for relapsing-remitting multiple sclerosis (MS). We report a 23-year-old woman with childhood onset relapsing-remitting MS treated with IFNβ-1b who developed overt chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) immediately after therapy. A baseline conduction study before IFNβ-1b therapy revealed decreased motor conduction velocities and prolonged F wave latencies in several nerves, but there was no neurological sign indicating neuropathy. The existence of subclinical demyelinating neuropathy before IFNβ-1b treatment was suggested, although the clinical criteria for CIDP were unfulfilled. Following two months of IFNβ-1b therapy, numbness of her right upper and lower limbs progressively worsened and all tendon reflexes were depressed. Electrophysiologically, F waves were not evoked in any limbs except for the left ulnar and tibial nerves, which showed marked prolongation of F wave latencies. Moreover, subclinical hyperthyroidism developed in association with high titers of anti-thyroglobulin and anti-thyroid peroxydase antibodies, which were negative before IFNβ-1b therapy. These findings indicated that peripheral demyelination worsened at the nerve roots after IFNβ-1b therapy. In addition to the development of autoimmune thyroid disease, the patient now fulfilled the criteria for probable CIDP. Along with the results of a previous report demonstrating IFNβ-induced CIDP development in patients with childhood MS, this case underscores IFNβ as a potential risk factor for CIDP in patients with childhood onset MS.
- 社団法人 日本内科学会の論文
- 2005-01-01
著者
-
TANIWAKI Takayuki
Department of Neurology, Graduate School of Medical Sciences, Kyushu University
-
KIRA Jun-ichi
Department of Neurology, Graduate School of Medical Sciences, Kyushu University
-
NOMURA Takuo
Department of Cardiovascular Surgery, Saiseikai Nakatsu Hospital
-
Nomura Takuo
Department Of Cardiovascular Surgery Saiseikai Nakatsu Hospital
-
Nomura Takuo
Department Of Neurology Neurological Institute Graduate School Of Medical Sciences Kyushu University
-
Kira Jun-ichi
Departments Of Neurology
-
Kira Jun-ichi
Department Of Neurology Graduate School Of Medical Sciences Kyushu University
-
Kira Jun-ichi
Department Of Neurology Neurological Institute Graduate School Of Medicine Kyushu University 60
-
Murai Hiroyuki
Departments Of Neurology
-
MATSUSE Dai
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu Univers
-
OCHI Hirofumi
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu Univers
-
TASHIRO Kenshi
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu Univers
-
Matsuse Dai
Department Of Neurology Neurological Institute Graduate School Of Medical Sciences Kyushu University
-
Ochi Hirofumi
Departments Of Neurology
-
Ochi Hirofumi
Department Of Molecular Immunology Medical Institute Of Bioregulation Kyushu University
-
Tashiro Kenshi
Department Of Neurology Neurological Institute Graduate School Of Medical Sciences Kyushu University
-
Taniwaki Takayuki
Department Of Clinical Neurophysiology Graduate School Of Medical Sciences Neurological Institute Fa
-
Taniwaki Takayuki
Department Of Neurology Neurological Institute Graduate School Of Medical Sciences Kyushu University
-
MURAI Hiroyuki
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
関連論文
- Non-invasive Evaluation of Face and Motion Perception in Humans
- PET evaluation of the relationship between D_2 receptor binding and glucose metabolism in patients with parkinsonism
- Novel missense mutations in the human lysosomal sialidase gene in sialidosis patients and prediction of structural alterations of mutant enzymes
- Autonomous Proliferation of HTLV^-CD4^+ T Cell Clones Derived from Human T Cell Leukemia Virus Type I (HTLV-I)-Associated Myelopathy Patients
- Mitral regurgitation resulting from the consecutive multiple perforations by infective endocarditis mimicking the isolated anterior mitral cleft
- Muscle Strength is a Marker of Insulin Resistance in Patients with Type 2 Diabetes : A Pilot Study
- Transient Burning Pain in the Ipsilateral Orbit as an Initial Manifestation of Dorsal Pontine Hemorrhage : Case Report
- Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population
- Neurological signs and symptoms in patients with chronic PCB poisoning (Yusho accident) for more than 36 years
- Exacerbation of Chronic Inflammatory Demyelinating Polyradiculoneuropathy during Interferonβ-1b Therapy in a Patient with Childhood-onset Multiple Sclerosis
- High Incidence of Subclinical Peripheral Neuropathy in Myelitis with HyperlgEaemia and Mite Antigen-specific IgE (Atopic Myelitis): an Electrophysiological Study
- Myelitis Associated with Atopic Disorders in Japan: a Retrospective Clinical Study of the Past 20 Years
- Hyperprolactinemia in Optico-spinal Multiple Sclerosis
- Ocular dominancy in conjugate eye movements at reading distance
- Surgical Removal of a Tilted Temporary Inferior Vena Cava Filter Incorporated with a Large Thrombus : Report of a Case
- Changing behavioral patterns to promote physical activity with motivational signs
- Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc^ mice
- Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan
- Negative regulagtion of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptore via Lyn kinase activity
- Accumulation of stress-related proteins within the glomeruli of the rat olfactory bulb following damage to olfactory receptor neurons
- Girdle Sensation Masquerading as Splanchnopathy in Neurosarcoidosis
- An Autopsy Case of the Marburg Variant of Multiple Sclerosis (Acute Multiple Sclerosis)
- High Incidence of Subclinical Peripheral Neuropathy in Myelitis with HyperIgEaemia and Mite Antigen-specific IgE (Atopic Myelitis): An Electrophysiological Study.
- Corpus Callosum Atrophy in Patients with Hereditary Diffuse Leukoencephalopathy with Neuroaxonal Spheroids: An MRI-based Study
- Slowly Progressive Distal Muscular Atrophy of the Bilateral upper Limbs (O'Sullivan-McLeod Syndrome) Partially Alleviated by Intravenous Immunoglobulin Therapy