Rheumatoid Arthritis Complicated with Acute Interstitial Pneumonia Induced by Leflunomide as an Adverse Reaction
スポンサーリンク
概要
- 論文の詳細を見る
A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide. Because all bacteriology findings were negative, steroid pulse-therapy was initiated promptly due to the rapidity of chest X-ray progression and the deterioration of arterial blood oxygen pressure. Although cough was induced by methotrexate, interstitial pneumonia was not detected clinically before leflunomide administration. He finally died of respiratory failure 128 days after the onset of acute interstitial pneumonia. According to the post-market surveillance, as high as ∼1.1 % of the patients on leflunomide have developed interstitial pneumonia in Japan. It is important to emphasize that acute interstitial pneumonia due to leflunomide is a very severe and potentially fatal side effect.
- 社団法人 日本内科学会の論文
- 2004-12-01
著者
-
MINOTA Seiji
Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical School
-
NARA Hiroyuki
Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical School
-
OKAZAKI Hitoaki
Division of Clinical Immunology and Rheumatology, Department of Medicine, Jichi Medical School, Scho
-
Iwamoto Masahiro
Division Of Rheumatology And Clinical Immunology Jichi Medical School
-
Iwamoto Masahiro
Division Of Rheumatology And Clinical Immunology Department Of Medicine Jichi Medical University
-
Minota Seiji
Department Of Medicine Division Of Rheumatology & Clinical Immunology Jichi Medical School
-
Minota Seiji
Division Of Rheumatology And Clinical Immunology Department Of Internal Medicine Jichi Medical Schoo
-
Nara Hiroyuki
The Department Of Rheumatology And Clinical Immunology Jichi Medical School
-
Nara Hiroyuki
Division Of Rheumatology And Clinical Immunology Department Of Medicine Jichi Medical School
-
Kamata Yasuyuki
Division Of Rheumatology And Clinical Immunology Jichi Medical School
-
KAMIMURA Takeshi
Division of Rheumatology and Clinical Immunology, Jichi Medical School
-
HANEDA Kengo
Division of Rheumatology and Clinical Immunology, Jichi Medical School
-
MASUYAMA Junichi
Division of Rheumatology and Clinical Immunology, Jichi Medical School
-
Haneda Kengo
Division Of Rheumatology And Clinical Immunology Jichi Medical School
-
Masuyama Junichi
Division Of Rheumatology And Clinical Immunology Jichi Medical School
-
Kamimura Takeshi
Department Of Medicine Utsunomiya Social Insurance Hospital
-
Okazaki Hitoaki
Department Of Medicine Division Of Rheumatology & Clinical Immunology Jichi Medical School
-
Okazaki Hitoaki
Division Of Clinical Immunology And Rheumatology Department Of Medicine Jichi Medical School School
-
Kamimura Takeshi
Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical School
関連論文
- Efficacy and safety of mizoribine for the treatment of Sjogren's syndrome : a multicenter open-label clinical trial
- Serum levels of vasoactive intestinal peptide are elevated in patients with atopic dermatitis
- Rapidly Progressed Secondary Amyloidosis in a Patient with Mixed Connective Tissue Disease
- Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer
- Anti-HSP auto-antibodies enhance HSP-induced pro-inflammatory cytokine production in human monocytic cells via Toll-like receptors
- Rheumatoid Arthritis Complicated with Acute Interstitial Pneumonia Induced by Leflunomide as an Adverse Reaction
- von Recklinghausen Disease in a Patient with X-linked Agammaglobulinemia
- Dermatomyositis and cutaneous necrosis: report of five cases
- Histiocytic Cytophagic Panniculitis which Developed during Interferon-α Therapy
- Decrease in the levels of anti-cyclic citrullinated peptide antibody in Japanese patients with rheumatoid arthritis who responded to anti-tumor necrosis factor-α
- Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule
- Successful Treatment of a Patient with Rheumatoid Arthritis and IgA-Kappa Multiple Myeloma with Tocilizumab
- Acute Gout Attack in the Wrist Joint
- Elevated muscle enzymes in a patient with severe hypocalcemia mimicking polymyositis
- Sjogren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus
- Acute Immune Thrombocytopenic Purpura in a 90-year-old Woman Treated with Immunoglobulin as well as Glucocorticoid
- Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus
- Radiological features and therapeutic responses of pulmonary nontuberculous mycobacterial disease in rheumatoid arthritis patients receiving biological agents : a retrospective multicenter study in Japan
- Comment on "Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks" by Yokoe et al
- Therapeutic response of patients with adult Still's disease to biologic agents : multicenter results in Japan
- Influence of antibodies against infliximab and etanercept on the treatment effectiveness of these agents in Japanese patients with rheumatoid arthritis
- ANCA in Atheroembolism; Just a Coincidence or Bearing Cause and Effect?
- Marked Colonic Wall Thickening in Lupus Enteritis
- Interleukin-18 in Adult-onset Still's Disease: Treatment Target or Disease Activity Indicator?
- Progressive Multicentric Reticulohistiocytosis
- Radiographic Features of Rhupus Arthropathy