Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Aquaporin Superfamily (Superaquaporins) : Expansion of Aquaporins Restricted to Multicellular Organisms
スポンサーリンク
概要
- 論文の詳細を見る
Eleven aquaporins are identified in mammals. They all have highly conserved two asparagine-proline-alanine (NPA) boxes that are important for the formation of the water permeating pore. Recently we identified two new proteins in mammals distantly related to aquaporins (AQPs) with poorly conserved NPA boxes. Similarly poorly conserved AQP-like proteins were found in several genome projects of multicellular organisms. They may be subgrouped as the AQP superfamily or superaquaporins. Their function is still unknown. AQP11 knockout mice suffer from polycystic kidneys and neonatal fatality. The identification of superaquaporins will provide new insights into the role of AQPs in organogenesis.
- 社団法人 日本薬理学会の論文
- 2004-11-20
著者
-
SASAKI Sei
Department of Nephrology, Tokyo Medical and Dental University Graduate School
-
Sakube Yasuji
自治医科大学 腎臓内科学部門
-
Sakube Yasuji
Department Of Biology Graduate School Of Sciences Okayama University
-
Sakube Yasuji
Department Of Biology Faculty Of Science Okayama University
-
MORISHITA Yoshiyuki
Department of Nephrology, Jichi Medical School
-
ISHIBASHI Kenichi
Division of Molecular Biology Research, Clinical Research Center, Chiba-East National Hospital
-
Ishibashi Kenichi
Division Of Clinical Pharmacology And Terapeutics Department Of Internal Medicine Jikei University S
-
Sasaki Sei
Department Of Nephrology Graduate School Of Medicine Tokyo Medical And Dental University
-
Sasaki Sei
Department Of Nephrology Tokyo Medical & Dental University Graduate School
-
Morishita Yoshiyuki
Department Of Nephrology Jichi Medical School
-
Ishibashi Kenichi
Division Of Molecular Biology Research Clinical Research Center Chiba-east National Hospital
-
Morishita Yoshiyuki
Department Of Biomedical Food Research National Institute Of Health
関連論文
- Expression of bone type 1 PTH receptor in rats with chronic renal failure
- Aquaporins in the body
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Aquaporin Superfamily (Superaquaporins) : Expansion of Aquaporins Restricted to Multicellular Organisms
- Mutations and Expressions of the Tropomyosin Gene and the Troponin C Gene of Caenorhabditis elegans
- PPARγ2 Pro12Ala Polymorphism and Insulin Resistance in Japanese Hypertensive Patients
- Insulin Resistance and Angiotensin Converting Enzyme Polymorphism in Japanese Hypertensive Subjects
- Inhibitory Effects of Insulin on Intracellular Calcium and Aggregatory Response of Platelets Are Impaired in Hypertensive Subjects with Insulin Resistance
- -1260- COMPARISON OF A NEW ANALYSIS OF HEART RATE FLUCTUATIONS RELATED TO RESPIRATION AND BLOOD PRESSURE VARIABILITY WITH A CONVENTIONAL POWER SPECTRAL ANALYSIS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1044- INSULIN SENSITIVITY AND INTRACELLULAR CALCIUM RESPONSE BY INSULIN IN HYPERTENSIVE SUBJECTS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Role of cytokines in anaphylactoid reaction with marked eosinophilia in a hemodialysis patient
- A female patient with malarial nephropathy
- Differential Effects of Hyperosmolality on Na-K-ATPase and Vasopressin-Dependent cAMP Generation in the Medullary Thick Ascending Limb and Outer Medullary Collecting Duct
- A familial case of mitochondrial disease resembling Alport syndrome
- Glomerulonephritis after Methicillin-resistant Staphylococcus aureus Infection Resulting in End-stage Renal Failure
- IgA Nephropathy with Complement Deficiency
- Chronic Renal Failure Due to Granulomatous Interstitial Nephritis in Sarcoidosis: Response to Corticosteroid Therapy
- Chloride transport across kidney epithelia through ClC chloride channels
- Single-Channel Properties of Volume-Sensitive Cl^- Channel in ClC-3-Deficient Cardiomyocytes
- Mitogen-Activated Protein Kinase Cascade and Cell Cycle-Related Genes in the Kidney
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Preface
- evidence-based practice guideline for the treatment of chronic kidney disease
- HLA-DRB1^*0410-Restricted Recognition of XAGE-1b_ Peptide by CD4 T Cells
- Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo
- Calcium-Alkali Syndrome-Like Symptoms Manifested by Daily Alphacalcidol and Thiazide
- Progression of Kidney Failure in Patients with Non-diabetic Chronic Kidney Disease under Combination Therapy in Japan : Development of Formula 1 and 2 versus Cockroft-Gault and MDRD Formulae, Aiming a Better Prediction of Renal Dysfunction
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
- Comparison of markers of circulating blood volume in hemodialysis patients
- Effect of anemia on cardiac disorders in pre-dialysis patients immediately before starting hemodialysis
- Regulation of WNK1 kinase by extracellular potassium
- Effect of Dietary Corn Oil, Butter and Beef Tallow on the Cecal Microflora and Short-Chain Fatty Acids in Rats
- Dexamethasone increases the phosphorylation of nephrin in cultured podocytes
- Daily variance of urinary excretion of AQP2 determined by sandwich ELISA method
- Close Association of Aquaporin-2 Internalization with Caveolin-1
- Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels
- Anti-centromere Antibody-positive Subjects Presenting with Hypertensive Emergency and Renal Dysfunction in the Absence of Skin Manifestations: A Variant of Systemic Sclerosis or a Novel Entity?
- Catheter-related Bacteremia Caused by Agrobacterium radiobacter in a Hemodialysis Patient
- Effects of sevelamer hydrochloride on mortality, lipid abnormality and arterial stiffness in hemodialyzed patients : a propensity-matched observational study
- The impact of hyporesponsiveness to erythropoietin-stimulating agents on time-dependent mortality risk among CKD stage 5D patients : a single-center cohort study
- Anti-centromere antibody is an independent risk factor for chronic kidney disease in patients with primary biliary cirrhosis
- Hereditary nephrogenic diabetes insipidus in Japanese patients : analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2
- Microorganisms Responsible for Controlling the Populations of Escherichia coli and Enterococcus and the Consistency of Cecal Contents in the Chicken