Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
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概要
- 論文の詳細を見る
Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signaling cascades also induce this sorting. Recently, AQP2-binding proteins that directly regulate this trafficking have been uncovered: SPA-1, a GTPase-activating protein for Rap1, and cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanism of AQP2 and its defect causing nephrogenic diabetes insipidus.
- 社団法人 日本薬理学会の論文
- 2004-11-20
著者
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SASAKI Sei
Department of Nephrology, Tokyo Medical and Dental University Graduate School
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Sasaki Sei
Department Of Nephrology Graduate School Of Medicine Tokyo Medical And Dental University
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Sasaki Sei
Department Of Nephrology Graduate School Tokyo Medical And Dental University
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Noda Yumi
Department Of Nephrology Graduate School Of Medicine
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Noda Yumi
Department Of Autonomic Physiology Medical Research Institute Tokyo Medical And Dental University
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Noda Yumi
Department Of Nephrology Graduate School Tokyo Medical And Dental University
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