Recurrent Small-Artery Disease in Hyperhomocysteinemia : Widowers' Stroke Syndrome?
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概要
- 論文の詳細を見る
Hyperhomocysteinemia is thought to cause ischemic strokes. We report two middle-aged widowers with frequent recurrences of small-artery strokes, two capsular infarcts and a thalamic hemorrhage in one patient, and two thalamic and pontine infarcts in the other. Blood tests following the final stroke showed hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T gene mutation, with low concentration of vitamin B6. Multivitamin supplementation normalized plasma homocysteine levels in both patients. Hyperhomocysteinemia is treatable; therefore, serum homocysteine should be measured as a potential risk factor for stroke recurrence in relatively young patients with recurrent small-artery infarctions or hemorrhage, especially those with insufficient lifestyle factors.
- 社団法人 日本内科学会の論文
- 2004-09-01
著者
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OKADA Yasushi
Department of Cerebrovascular Disease, National Hospital Organization Kyushu Medical Center
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Okada Yasushi
Cerebrovascular Center And Clinical Research Institute National Kyushu Medical Center
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IBAYASHI Setsuro
Departments of Medicine & Clinical Science and Radiology
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Toyoda Kazunori
Department Of Cerebrovascular Disease And Clinical Research Institute National Kyushu Medical Center
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FUJIMOTO Shigeru
Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Cente
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Hagiwara Noriko
Department of Cerebrovascular Disease, National Kyushu Medical Center, Fukuoka
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Uwatoko Takeshi
Department of Cerebrovascular Disease, National Kyushu Medical Center, Fukuoka
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SHIMADA Toshifumi
Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Cente
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Ibayashi Setsuro
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences
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Fujimoto Shigeru
Cerebrovascular Center And Clinical Research Institute National Kyushu Medical Center
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Okada Yasushi
Department Of Biology Kagawa Medical School
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Okada Yasushi
Department Of Cerebrovascular Disease And Clinical Research Institute National Kyushu Medical Center
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Fujimoto Shigeru
Department Of Cerebrovascular Disease And Clinical Research Institute National Kyushu Medical Center
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Shimada Toshifumi
Department Of Cerebrovascular Disease And Clinical Research Institute National Kyushu Medical Center
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Toyoda Kazunori
Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Center
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Uwatoko Takeshi
Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Center
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IBAYASHI Setsuro
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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Hagiwara Noriko
Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Center
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