Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)
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概要
- 論文の詳細を見る
CD226 (DNAM-1) is an adhesion molecule involved in NK and T cell-mediated cytotoxicity against certain tumors. Here, we have identified the human poliovirus receptor-related (PRR) family members CD155 [poliovirus receptor (PVR)] and CD112 (nectin-2/PRR-2) as the ligands for human CD226. Ectopic expression of human CD155 and/or CD112 rendered mouse BW5147 T cells more susceptible to IL-2-activated T and NK cell-mediated cytotoxicity, and killing was specifically inhibited by anti-CD226 mAb, demonstrating functional interactions of CD226 with CD155 and CD112. Although the binding affinities between soluble CD226 and CD155 or CD112 were comparable, the homophilic interaction of cell-surface CD112 may adversely affect CD226 binding to CD112. We also demonstrate that ligation of CD226 and LFA-1 with their respective ligands cooperates in triggering cytotoxicity and cytokine secretion by T and NK cells.
- Oxford University Pressの論文
- 2004-04-01
著者
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Tahara (hanaoka)
Laboratory For Immune Receptor Riken Research Center For Allergy And Immunology Riken
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Shibuya Kazuko
Department Of Immunology Institute Of Basic Medical Sciences And Center For Tara Graduate School Of
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Honda Shin-ichiro
Department Of Immunology Institute Of Basic Medical Sciences And Center For Tara Graduate School Of
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Shibuya Kazuko
筑波大学 人間総合科学研究科免疫学
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MIYAMOTO Akitomo
Department of Immunology, Institute of Basic Medical Sciences
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SHIBUYA Kazuko
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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ONODA Yuko
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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ZHANG Hua
PRESTO, Japan Science and Technology Agency
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YAMAZAKI Satoshi
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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MIYAMOTO Akitomo
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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HONDA Shin-ichiro
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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LANIER Lewis
Department of Microbiology and Immunology and the Cancer Research Institute, University of Californi
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SHIBUYA Akira
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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Onoda Yuko
Laboratory For Immune Receptor Riken Research Center For Allergy And Immunology Riken
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Lanier Lewis
Department Of Microbiology & Immunology And The Cancer Research Institute
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Lanier Lewis
Department Of Microbiology And Immunology And The Cancer Research Institute University Of California
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Shibuya Akira
Department Of Immunology Institute Of Basic Medical Sciences And Center For Tara Graduate School Of
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Miyamoto Akitomo
Laboratory For Immune Receptor Riken Research Center For Allergy And Immunology Riken
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Yamazaki S
Laboratory For Immune Receptor Riken Research Center For Allergy And Immunology Riken
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Zhang Hua
Presto Japan Science And Technology Agency
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Tahara-Hanaoka Satoko
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, RIKEN
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