Tyrosinase Activity in Antitumor Compounds of Squid Ink
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概要
- 論文の詳細を見る
Previous studies have demonstrated antitumor activity in squid ink. This study was carried out to clarify the key component of, and the role of tyrosinase in the antitumor activity. The antitumor fraction, which contains illexin-peptidoglycan, soluble melanin and tyrosinase activity, was isolated from the defatted ink using Tris-HCl buffer extraction, DEAE Sephacel and Sephacryl S-300 chromatography. During the isolation procedure, the behavior of the tyrosinase activity exhibited the same pattern as the antitumor activity. The antitumor fraction could be separated by Phenyl Sepharose CL-4B chromatography into three fractions: illexin-peptidoglycan, tyrosinase and the complex of the two. The fraction containing illexin-peptidoglycan and tyrosinase showed the highest activity against the Meth A tumor in BALB/c mice. This suggests that both these components are needed for the antitumor activity of squid ink.
- 社団法人 日本食品科学工学会の論文
- 2000-08-01
著者
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NARAOKA Tetsushi
Aomori Advanced Industrial Technology Center
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MATSUE Hajime
Aomori Advanced Industrial Technology Center
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Matsue H
Aomari Univ. Health And Welfare Aomori Jpn
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CHUNG Hun-Sik
Aomori Advanced Industrial Technology Center
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UCHISAWA Hidemitsu
Aomori Advanced Industrial Technology Center
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SASAKI Jin-ichi
Department of Bacteriology, Hirosaki University School of Medicine
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Sasaki Jin-ichi
Department Of Bacteriology Hirosaki University School Of Medicine
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Uchisawa H
Aomori Industrial Res. Center Aomori Jpn
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