Differences in Responsiveness of Mouse Strain against p-Benzoquinone as Assessed by Non-Radioisotopic Murine Local Lymph Node Assay
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概要
- 論文の詳細を見る
The non-radioisotopic modification of murine local lymph node assay (LLNA) by using 5-bromo-2-deoxyuridine (BrdU) was conducted to investigate the strain-related difference of the responsiveness of mice to p-benzoquinone (PBQ) with BALB/cAnN, CBA/JN and CD-1 mouse strains. Strain and dose related differences were analyzed by two-way analysis of variance (two-way ANOVA). CBA/JN was considered to be the highest responsive strain to PBQ, and interaction was detected between CD-1 and each of the other inbred strains. These results support the recommendation in the OECD test guideline 429 and the skin sensitization test guideline of US-EPA with regard to the selection of mouse strain for LLNA.
- 社団法人 日本実験動物学会の論文
著者
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YAMASAKI Kanji
Hita Research Laboratories, Chemicals Inspection and Testing Institute
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TAKEYOSHI Masahiro
Hita Laboratory, Chemicals Evaluation and Research Institute (CERI)
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NODA Shuji
Chemicals Evaluation and Research Institute
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MUROI Takako
Chemicals Evaluation and Research Institute
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YAMASAKI Kanji
Chemicals Evaluation and Research Institute
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Yamasaki Ken-ichi
Institute Of Laboratory Animals Faculty Of Medicine Kyoto University
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Noda Shuji
Chemicals Evaluation And Research Institute Chemicals Assessment Center
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Noda Shuji
Hita Research Laboratories Chemical Biotesting Center Chemicals Inspection & Testing Institute
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Takatuki Mineo
Chemicals Evaluation And Research Institute
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Takeyoshi Masahiro
Hita Research Laboratories Chemical Biotesting Center Chemicals Inspection & Testing Institut
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Takeyoshi Masahiro
Hita Laboratory Chemicals Evaluation And Research Institute (ceri)
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Noda Shuji
Hita Laboratory Chemicals Evaluation And Research Institute
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Yamasaki Kanji
Hita Laboratory Chemicals Evaluation And Research Institute
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Takeyoshi Masahiro
Chemicals Evaluation And Research Institute
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Takatsuki Mineo
Hita Laboratory Chemicals Evaluation And Research Institute
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