Effects of Age and Weaning on the Immature Rat Uterotrophic Assay Using Ethynylestradiol

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概要

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• The purpose of this study was to evaluate the most appropriate rat age for the start of administration, and the effect of weaning, in the immature rat uterotrophic assay using ethynylestradiol (EE). Animals weaned on postnatal day (PND) 20 were administered subcutaneously EE at doses of 0.06-6 μg/kg/day for 3 days beginning on PND 21, 23 or 25. EE at the same doses was also administered to rats weaned on PND 17 or 20 from PND 21 for 3 days. Although uterine weight was significantly increased in the rats given 0.6-6 μg/kg EE in both of the studies, the percentage increase relative to the control in each group given EE from PND 21 and weaned on PND 20 was higher than in those groups given EE from PND 23 or 25, and the group weaned on PND 17.

• 社団法人　日本実験動物学会の論文

著者

• NODA Shuji

  Chemicals Evaluation and Research Institute

• MUROI Takako

  Chemicals Evaluation and Research Institute

• YAMASAKI Kanji

  Chemicals Evaluation and Research Institute

• Yamasaki Ken-ichi

  Institute Of Laboratory Animals Faculty Of Medicine Kyoto University

• SAWAKI Masakuni

  Chemicals Assessment Center, Chemicals Evaluation and Research Institute

• Noda Shuji

  Chemicals Evaluation And Research Institute Chemicals Assessment Center

• Yamasaki Kanji

  Chemicals Assessment Center Chemicals Evaluation And Research Institute

• TAKATUKI Mineo

  Chemicals Evaluation and Research Institute, Chemicals Assessment Center

• Sawaki Masakuni

  Chemicals Assessment Center Chemicals Evaluation And Research Institute

• Takatuki Mineo

  Chemicals Evaluation And Research Institute

• Yamasaki Kanji

  Hita Laboratory Chemicals Evaluation And Research Institute

• Takatsuki Mineo

  Chemicals Evaluation And Research Institute

• Noda Shuji

  Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii, Hita, Oita 877-0061, Japan

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