光学活性グリシッド酸エステル工業製造用膜バイオリアクターの開発

概要

論文の詳細を見る
An optically active (2R, 3S) -3- (4-methoxyphenyl) glycidic acid methyl ester ((-) MPGM) was an important intermediate for the synthesis of diltiazem hydrochloride which is a typical calcium channel blocker. To establish a practical production system of this useful chiral compound, a hollow-fiber ultrafiltration membrane bioreactor has been developed. In the bioreactor system, the lipase from Serratia marcescens was immobilized on the spongy layer of the shell side of a membrane by means of physical adsorption. Asymmetric hydrolysis was carried out semi-continuously in a membrane bioreactor circulating both toluence solution containing racemate ((±) MPGM) in the shell loop and aqueous solution cotaining NaHSO3 in the lumen loop. The membrane bioreactor permitting the simultaneous achievement of enzyme reaction and phase separation was highly efficient for industrial production of (-) MPGM. This paper briefly describes the process of research development of the industrial-scale membrane bioreactor. In addition, our recent works relating to membrane bioreactors were presented.
日本膜学会の論文
1996-01-01