A Decrease in the Amount and Function of Inhibitory GTP-Binding Protein in the Resistance Small Artery From Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory GTP-binding protein (Gi protein) plays an important role in regulation of vascular tone. Many studies have implicated the role of Gi protein in conduit vessels. However, the physiological role of Gi protein in the control of peripheral microvascular tone in hypertension has not been established yet. Therefore, we investigated the concentration of Gi protein in the peripheral resistance arteries and aorta in the spontaneously hypertensive rats (SHR), normotensive Wistar-Kyoto rats (WKY) and renovascular hypertensive rats (RHR), using immunohistochemical methods semiquantitatively. Changes in the function of Gi protein in relation to α2-adrenoceptor were also investigated by microcannulation techniques. We have shown that the amount of α2 subunits of Gi protein in the cremaster small artery was significantly lower in SHR aged 4 weeks and older than in age-matched WKY and that there were no significant differences between RHR and WKY. We also demonstrated that the function of Gi protein in relation to α2-adrenoceptor was already lower in SHR before the onset of hypertension. The quantitative and functional decline in Gi protein in the smooth muscle cells of peripheral small arteries were observed in SHR even before the onset of hypertension, whereas rats with secondary hypertension did not exhibit this finding.
- 社団法人 日本薬理学会の論文
- 1999-02-01
著者
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Iwasaki Tadaaki
First Department of Internal Medicine, Hyogo College of Medicine
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Masutani Mitsuo
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Ohyanagi Mitsumasa
Division Of Coronary Heart Disease Hyogo College Of Medicine
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Masutani Motomaru
First Department Of Internal Medicine Hyogo College Of Medicine
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Iwasaki T
兵庫医科大学第一内科
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Iwasaki Tadaaki
Department Of Internal Medicine Division Of Coronary Heart Disease Hyogo College Of Medicine
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Ishigami Yasuhiro
First Department Of Internal Medicine Hyogo College Of Medicine
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Masutani Motomaru
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Masai Miho
Division Of Coronary Heart Disease Department Of Internal Medicine Hyogo College Of Medicine
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OHYANAGI Mitsumasa
First Department of Internal Medicine, Hyogo College of Medicine
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Iwasaki Tadaaki
First Department Of Internal Medicine And Department Of Nuclear Medicine Hyogo College Of Medicine
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SHIBUYA Jun
First Department of Internal Medicine, Hyogo College of Medicine
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Shibuya Jun
First Department Of Internal Medicine Hyogo College Of Medicine
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Ohyanagi Mitsumasa
First Department Of Internal Medicine And Department Of Nuclear Medicine Hyogo College Of Medicine
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Masutani Motomaru
First Department Of Internal Medicine Hyogo College Of Medicin
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