Experience with Oseltamivir in the Control of Nursing Home Influenza A Outbreak
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概要
- 論文の詳細を見る
Objective Influenza outbreaks have revealed that elderly persons are a great risk of death and serious complications after infection. The administration of oseltamivir, a neuramidase inhibitor, is effective for prophylaxis of influenza and to reduce disease duration and severity in healthy adults with naturally acquired febrile influenza. To clarify the usefulness of oseltamivir in the elderly we administered oseltamivir to all residents when an influenza A outbreak occurred in a nursing home.Patients Sixty-eight residents in the nursing home were investigated in which the influenza A outbreak occurred; 32 residents had fever and 28 residents were positive for influenza A with direct enzyme immunoassay.Methods Oseltamivir was administered at 75 nig twice daily for 5 days to all residents.Results Oseltamivir almost inhibited symptom onset in the influenza A-positive afebrile group. Initiation at 0 hour (22 cases), 1-12 hours (4 cases), 13-24 hours (5 cases) or 72 hours (1 case) from onset of symptoms was associated with mean fever durations of 26±18 hours, 38±21 hours, 54±12 hours and 120 hours, respectively, indicating that earlier initiation of therapy was associated with faster resolution of fever in elderly patients. Oseltamivir may be effective for household prophylaxis in the elderly persons. Oseltamivir administration was well tolerated in elderly persons.Conclusion Oseltamivir is effective for the reduction or prophylaxis of influenza A infection in elderly persons.(Internal Medicine 41: 366-370, 2002)
- 社団法人 日本内科学会の論文
- 2002-05-01
著者
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TAKAHASHI MAMORU
The Third Division, Department of lnternal Medicine, Kyoto University Hospital
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SHIJUBO Noriharu
the Third Department of Internal Medicine, Sapporo Medical University School of Medicine
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ABE Shosaku
the Third Department of Internal Medicine, Sapporo Medical University School of Medicine
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YAMADA Gen
the Third Department of Internal Medicine, Sapporo Medical University School of Medicine
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Yamada Gen
Third Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Yamada Gen
The Third Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Abe Shosaku
The Third Department Of Internal Medicine Sapporo Medical University
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TOKUNOH Tetsuya
The First Department of Internal Medicine Hokkaido Prefectural Esashi Hospital
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SUZUKI Takashi
The First Department of Internal Medicine Hokkaido Prefectural Esashi Hospital
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Shijubo Noriharu
Department Of Respiratory Disease Sapporo Hospital Hokkaido Railway Co.
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Shijubo Noriharu
Department Of Respiratory Medicine Sapporo Hospital Hokkaido Railway Company
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Shijubo Noriharu
The Third Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Abe Shosaku
The Third Department Of Internal Medicine
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Takahashi Mamoru
The Third Department Of Internal Medicine Sapporo Medical University School Of Medicine
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