Nucleotide Sequence of Endothelin-B receptor Gene Reveals Origin of Piebald Mutation in Laboratory Mouse

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概要

• 論文の詳細を見る

• Piebald (Ednrbs) is a coat color mutation of laboratory mice caused by a decreased expression of endothelin-B receptor gene (Ednrb). The IITES and JF1 mouse strains, whose origins are believed to be different from those of the common laboratory inbred strains, also show a phenotype similar to Ednrbs. In the present study, we found that the nucleotide sequence of the Ednrb gene of the IITES and JF1 mice is identical to that of the Ednrbs allele, Ednrb s allele has an RFLP of the Ednrb gene identical with that of M. m. molossinus but different from other subspecies, and at least particular regions of chromosome 14 proximal to the Ednrb locus of the IITES and JF1 strains are derived from M. m. molossinus. These findings clearly indicate that the Ednrbs allele of the laboratory mice has its origin in M. m. molossinus.

• 社団法人　日本実験動物学会の論文
• 1998-10-01

著者

• KUNIEDA Tetsuo

  Faculty of Agriculture, Okayama University

• Kunieda Tetsuo

  Faculty Of Agriculture Okayama University

• Tsudzuki Masaoki

  Faculty Of Applied Biological Science Hiroshima Universtiy

• KUMAGAI Taeko

  Faculty of Agriculture, Okayama University

• WADA Adumi

  College of Agriculture, Osaka Prefecture University

• NISHIMURA Masahiko

  Hamamatsu Universtiy School of Medicine

• Kumagai Taeko

  Faculty Of Agriculture Okayama University

• Wada Adumi

  College Of Agriculture Osaka Prefecture University

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