Kamatani Naoyuki | Laboratory For Statistical Analysis Center For Genomic Medicine Riken
スポンサーリンク
概要
- Kamatani Naoyukiの詳細を見る
- 同名の論文著者
- Laboratory For Statistical Analysis Center For Genomic Medicine Rikenの論文著者
関連著者
-
Kamatani Naoyuki
Laboratory For Statistical Analysis Center For Genomic Medicine Riken
-
Nitta Kosaku
Department of Medicine, Kidney Center, Tokyo Womens Medical University
-
Nakamura Yusuke
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of T
-
Kamatani Naoyuki
Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN
-
Takahashi Atsushi
Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN
-
Makino H
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine And Denti
-
WATANABE Tsuyoshi
Fukushima Medical University
-
Muratani H
Department Of Clinical Pharmacology And Therapeutics Tohoku University
-
KAMATANI Naoyuki
Institute of Rheumatology, Tokyo Women's Medical University School of Medicine
-
Asaka Takahisa
Cardiovascular Center Yokosuka Kyosai Hospital
-
Kamatani Naoyuki
Institute Of Rheumatology Aoyama Hospital Tokyo Women's Medical University
-
Makino Hirofumi
Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
-
Matsuoka Hiroaki
大阪大学 医学系研究科老年･腎臓内科学
-
NAKAO Kazuwa
EBM Research Center, Kyoto University Graduate School of Medicine
-
Mizuno Kyoichi
日本医科大学 内科学
-
Funahashi Tohru
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
-
Suga H
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
-
Hori Masatsugu
大阪大学 医学系研究科循環器内科学
-
Tomino Y
Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine
-
Mizuno Kyoichi
Division Of Cardiology Hepatology Geriatrics And Integrated Medicine Department Of Internal Medicine
-
Kawamoto Manabu
国立医薬品食品衛生研究所
-
Kawamoto Manabu
Institute Of Rheumatology Tokyo Women's Medical University
-
Yasutake Masahiro
Division Of Cardiology Department Of Internal Medicine Nippon Medical School
-
Suga Hiroyki
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
-
Mizuno Kyoichi
First Department Of Internal Medicine Nippon Medical School
-
Tabara Yasuharu
国立循環器病センター研究所 疫学部
-
Tabara Yasuharu
西予市立野村病院 内科
-
MIYAMOTO Yoshinari
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN
-
IKEGAWA Shiro
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN
-
Tsubakihara Yoshiharu
大阪府立病院機構大阪府立急性期総合医療センター 腎臓･高血圧内科
-
SATO Hiroshi
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
MIZUNO Hiroya
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
HORI Masatsugu
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
Matsuda H
Department Of Cardiovascular Surgery Hyogo Medical College
-
Matsuda Hikaru
Cardiovascular Division Osaka Polici Hospital
-
ISEKI Kunitoshi
University of the Ryukyus
-
Matsuda Koichi
Department Of Internal Medicine Tokyo Metropolitan Komagome Hospital
-
Yumura Wako
Department of Nephrology, Jichi Medical University
-
Kawamoto Manabu
Division Of Genomic Medicine Department Of Advanced Biomedical Engineering And Science Tokyo Women&a
-
Yanagisawa Masao
Department Of Internal Medicine Division Of Cardiology Nippon Medical School Tama-nagayama Hosipital
-
Takeda Hiroshi
Department Of Medical Information Science Osaka University Graduate School Of Medicine
-
Takagi Hiromichi
Department Of Medical Information Science Osaka University Graduate School Of Medicine
-
Nakajima Tadahisa
Department Of Metabolic Medicine Osaka University Graduate School Of Medicine
-
Iseki Kunitoshi
琉球大学 医学研究科臨床薬理学
-
Makino Hirofumi
岡山大学 医歯学総合研究科腎･免疫･内分泌代謝内科学
-
Itoh Sadayoshi
Tohoku University
-
Ito Sadayoshi
Division Of Nephrology Endocrinology And Vascular Medicine Department Of Medicine Tohoku University
-
MATSUZAWA Yuji
Sumitomo Hospital
-
Ozaki Kouichi
Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN
-
Tsunoda Tatsuhiko
Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN
-
Tanaka Toshihiro
Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN
-
Kubo Michiaki
Laboratory for Genotyping, Center for Genomic Medicine, RIKEN
-
Takano Hitoshi
Division of Cardiology, The First Department of Internal Medicine
-
Yoshimatsu Hironobu
Department of Internal Medicine 1, Faculty of Medicine, Oita University
-
ITO Sadayoshi
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Internal Medicine, Tohoku
-
SAKATA Toshiie
Department of Nutritional Sciences, Faculty of Nutritional Science, Nakamura Gakuen University
-
Matsuzawa Yuji
Department of Internal Medicine, Sumitomo Hospital
-
ITO Sadayoshi
Tohoku University
-
KOHNO Masakazu
Kagawa University
-
MUROHARA Toyoaki
Nagoya University
-
TAKESHITA Akira
Kyushu University
-
Kitamura K
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
-
Kita Toru
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
NAKAO Kazuwa
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Dai Jin
理化学研究所ゲノム医科学研究センター 骨関節疾患研究チーム
-
Uchida Keiko
Department of Medicine, Kidney Center, Tokyo Womens Medical University
-
KAWAGUCHI Yasushi
Institute of Rheumatology, Tokyo Women's Medical University School of Medicine
-
Tsutsumi Yoshiaki
国立循環器病センター
-
Yasuda Yoshinari
National Hospital Organization
-
Funahashi Tohru
Department of Metabolic Medicine, Graduate School of Medicine
-
Miyatake Nobuyuki
Okayama Health Foundation Okayama Jpn
-
Yui Yoshiki
Division Of Cardiorogy Osaka Red Cross Hospital
-
伊藤 貞嘉
東北大学病院 腎高血圧内分泌科
-
MAKINO Hirofumi
Department of Medicine III, Okayama University Medical School
-
KIMURA Kenjiro
St. Marianna University School of Medicine
-
Tabara Yasuharu
自治医科大学 循環器内科
-
Seino Yoshihiko
Cardiovascular Center Chiba-hokusoh Hospital Nippon Medical School
-
Kita Toru
Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University
-
Katsuya Tomohiro
東北大学 臨床薬学
-
WATANABE Tsuyoshi
Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine
-
Iseki K
University Of The Ryukyus
-
Iseki Kunitoshi
琉球大学医学部附属病院 血液浄化療法部
-
Makino Hirofumi
Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Sci. Okayama Jpn
-
Makino Hirofumi
大阪大学 医学系研究科老年･腎臓内科学
-
Kashiwagi A
Department Of Medicine Shiga University Of Medical Science
-
Yasujima Minoru
東北大学 医系研究内部障害学分野
-
Masaki Hiroya
The Cardiovascular Center Kansai Medical University
-
Matsubara Hiroaki
公立南丹病院 循環器内科
-
Kobayashi Naohiko
Kawasaki Medical School
-
Kayaba Kazunori
Department Of Cardiology Jichi Medical University
-
Kario Kazuomi
自治医科大学 地域医療学
-
野中 聡
旭川医科大学耳鼻咽喉科・頭頸部外科学講座
-
野中 源一郎
九州大学薬学部
-
林 達哉
旭川医科大学耳鼻咽喉科・頭頸部外科学講座
-
SAITO Yasushi
Chiba University
-
ISOBE Mitsuaki
Department of Cardiovascular Medicine, Tokyo Medical and Dental University
-
SAKATA Yasuhiko
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
HORI Masatsugu
Osaka Medical Center for Cancer and Cardiovascular Disease
-
Inoue Katsumi
Department of Cardiology, Kokura Memorial Hospital
-
Aoki Asako
Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN
-
Odashiro Keita
Department of Cardiology, Kokura Memorial Hospital
-
Nobuyoshi Masakiyo
Department of Cardiology, Kokura Memorial Hospital
-
Nakamura Yusuke
Center for Genomic Medicine, RIKEN
-
Aoki Asako
Cardiovascular Disease, Center for Genomic Medicine, RIKEN
-
Ozaki kouichi
Cardiovascular Disease, Center for Genomic Medicine, RIKEN
-
Yasutake Masahiro
Division of Cardiology, The First Department of Internal Medicine
-
Mizuno Kyoichi
Division of Cardiology, The First Department of Internal Medicine
-
Tanaka Toshihiro
Cardiovascular Disease, Center for Genomic Medicine, RIKEN
-
Horio Masaru
Ehime University
-
Takahashi Atsushi
Department Of Cardiovascular Medicine Wakayama Medical University
-
林田 孝平
国立循環器病センター放射線診療部
-
北 徹
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
-
北 徹
京都大学大学院医学研究科循環器内科学
-
TAMURA Kouichi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of
-
OIKAWA Shinichi
Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School
-
IMAIZUMI Tsutomu
Kurume University
-
ISHIMITSU Toshihiko
Dokkyo Medical University
-
KAWANO Yuhei
National Cardiovascular Center
-
KIMURA Genjiro
Nagoya City University
-
HIRAWA Nobuhito
Yokohama City University
-
KATSUYA Tomohiro
Osaka University
-
KUMAGAI Hiroo
National Defense Medical College
-
TSUBAKIHARA Yoshiharu
Osaka General Medical Center
-
TSUTSUI Hiroyuki
Hokkaido University
-
UEHARA Yoshio
University of Tokyo
-
URA Nobuyuki
Teine Keijinkai Hospital
-
OIKAWA Shinichi
Department of Internal Medicine, Nippon Medical School
-
HIRAWA Nobuhito
Department of Internal Medicine and Cardiorenal Medicine Yokohama City University Graduate School of
-
KAGAMI Shoji
Department of Pediatrics, School of Medicine, University of Tokushima
-
Kikuchi Kenjiro
Second Department Of Internal Medicine Sapporo Medical College
-
Sasano H
Tohoku University 21st Century Coe Program 'comprehensive Research And Education Center For Pla
-
Takishita S
University Of The Ryukyus
-
Kita Toru
京都大学 医学研究科循環器内科学
-
Kita Toru
Department Of Cardiovascular Medicine Kobe City Medical Center General Hospital
-
Shi Dongquan
中華人民共和国
-
Shi Dongquan
Center Of Diagnosis And Treatment For Joint Disease Drum Tower Hospital Affiliated To Medical School
-
Dai Jin
The Center Of Diagnosis And Treatment For Joint Disease Drum Tower Hospital Affiliated To Medical Sc
-
Qin Jianghui
中華人民共和国
-
SUZUKI Yoshihiko
Suzuki clinic
-
喜多 義邦
Division Of Preventive Cardiology National Cardiovascular Center
-
Sumida Hitoshi
Kumamoto AMI Study Group
-
Nobuyoshi Masakiyo
Kokura Memorial Hospital
-
Inoue Katsumi
松江赤十字病院 循環器科
-
梶原 哲郎
Tochigi Cancer Center Hospital
-
梶原 哲郎
東京女子医科大学第二病院外科
-
Kamide Kei
国立循環器病センター 高血圧腎臓内科
-
Yoshida S
Chiba University
-
Akasaka Takashi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Sawa Yoshiki
Department Of Cardiovascular Surgery Osaka Graduate School Of Medicine
-
Morishima Y
Department Of Hematology Kinki University School Of Medicine
-
Takasaki I
Aichi Medical University
-
Iwakura K
Cardiovascular Center Sakurabashi Watanabe Hospital
-
Itoh Hiroshi
Division 1 Department Of Pathology Kobe University School Of Medicine
-
Takata Hiroki
Hokkaido University
-
Tsutsumi Yoshiaki
Genetics Division National Cancer Center Research Institute
-
HASHIMOTO Hiroshi
Department of Neurosurgery, Nara Medical University
-
Kotani Yasushi
国立循環器病センター 予防検診
-
KASHIHARA Naoki
Department of Internal Medicine, Kawasaki Medical School
-
橋本 周司
早稲田大学理工学術院 先進理工学研究科
-
Maeda Shiro
Laboratory for Diabetic Nephropathy, SNP Research Center, The Institute of Physical and Chemical Res
-
Koito Hitoshi
The Cardiovascular Center Kansai Medical University
-
Sakata Y
Center For Advanced Medical Engineering And Informatics Osaka University
-
Sato Yuichi
日本大学 医学部循環器内科学
-
Saito Y
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
-
Yamashita Shizuya
大阪大学 医学系研究科循環器内科学
-
FURUICHI Tatsuya
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN
-
MAEDA Koichi
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN
-
CHOU Chung-Tei
Division of Allergy-Immunology-Rheumatology, Department of Medicine, Taipei Veterans General Hospita
-
LIU Yu-Fen
Genome Research Center, National Yang-Ming University
-
LIU Ting-Chun
Genome Research Center, National Yang-Ming University
-
MORI Kanji
Department of Orthopaedic Surgery, Shiga University of Medical Science
-
IKARI Katsunori
Institute of Rheumatology, Tokyo Woman's Medical University
-
KUROSAWA Hisashi
Department of Orthopaedics Surgery, Juntendo University School of Medicine
-
INOUE Hisashi
Department of Orthopaedics Surgery, Juntendo University School of Medicine
-
TSAI Shih-Feng
Genome Research Center, National Yang-Ming University
-
Saito Yoshihiko
Department Of Clinical Cell Biology Chiba University Graduate School Of Medicine
-
FUJIOKA Tomoaki
Department of Urology, Iwate Medical University
-
Ura Nobuyuki
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Ura Nobuyuki
Second Department Of Internal Medicine Sapporo Medical Unversity School Of Medicine
-
Ura Nobuyuki
大阪大学 医学系研究科老年腎臓内科学
-
Kai Hisashi
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
-
Makino H
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine Dentistry
-
Kashiwagi Atsunori
Department Of Medicine Shiga University Of Medical Science
-
Ishimitsu Toshihiko
獨協医科大学 循環器内科
-
Ishimitsu Toshihiko
東京大学 第2内科
-
Ishimitsu Toshihiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
-
Kawano Yuhei
国立循環器病センター 高血圧腎臓内科
-
Tomino Yasuhiko
順天堂大学 腎臓内科学
-
Kimura Genjiro
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
-
Kashihara Naoki
Department Of Internal Medicine Division Of Nephrology Kawasaki Medical School
-
Kumagai Hiroo
慶応義塾大学 医学部内科学教室
-
Kumagai Hiroo
Department Of Internal Medicine School Of Medicine Keio University
-
Takishita Shuichi
琉球大学 循環系総合内科学
-
Kaneko Yoshihiro
Second Department Of Internal Medicine Yokohama City University Hospital
-
Hisamichi S
Tohoku University 21st Century Coe Program 'comprehensive Research And Education Center For Pla
-
Suzuki H
Saitama Medical University
-
Suzuki Hiromichi
Department Of Nephrology School Of Medicine Faculty Of Medicine Saitama Medical University
-
Kobayashi Shun-ichi
Shimane University
-
Yoshida K
Furukawa City Hospital
-
Yoshinaga Kaoru
The Second Department Of Internal Medicine Tohoku University School Of Medicine
著作論文
- OE-009 Identification of a Locus on Chromosome 5p that Confers Risk of Coronary Artery Disease by Genome Wide Association Study(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese
- New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations
- A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population
- Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population
- Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility
- High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population
- A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction
- Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction
- Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients
- Japanese single nucleotide polymorphism database for 267 possible drug-related genes
- Clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease
- Chronic kidney disease perspectives in Japan and the importance of urinalysis screening
- PJ-756 Aliskiren Reduces Leukocyte Recruitment in Acute Vascular Inflammation via Oxidative Stress-dependent, but Blood Pressure Independent Mechanisms(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
- Arterial Stiffness in Patients with Non-Diabetic Chronic Kidney Disease (CKD)
- Aortic Arch Calcification and Arterial Stiffness are Independent Factors for Diastolic Left Ventricular Dysfunction in Chronic Hemodialysis Patients
- PJ-224 Primal role of intracellular zinc in PKC-dependent monocyte signalling and adhesive interaction(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Patterns in the prevalence of hepatitis C virus infection at the start of hemodialysis in Japan
- Renal pathology of ANCA-related vasculitis : proposal for standardization of pathological diagnosis in Japan
- INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese
- Variations in the FTO gene are associated with severe obesity in the Japanese
- Long-term Effect of Combination Therapy with Mitiglinide and Once Daily Insulin Glargine in Patients who were Successfully Switched from Intensive Insulin Therapy in Short-term Study
- Intracellular lipid accumulation and insulin resistance in skeletal muscle and liver
- Therapeutic Efficacy of Mitiglinide Combined with Once Daily Insulin Glargine after Switching from Multiple Daily Insulin Regimen of Aspart Insulin and Glargine in Patients with Type 2 Diabetes Mellitus
- Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
- The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients
- Similarity of the allele frequency and linkage disequilibrium pattern of single nucleotide polymorphisms in drug-related gene loci between Thai and northern East Asian populations : implications for tagging SNP selection in Thais
- evidence-based practice guideline for the treatment of chronic kidney disease
- A nationwide survey of rapidly progressive glomerulonephritis in Japan : etiology, prognosis and treatment diversity
- Clinical assessment of atherosclerotic parameters and cardiac function in chronic hemodialysis patients
- Successful steroid treatment of a patient with autosomal dominant polycystic kidney disease complicated by sarcoidosis
- Management of anemia in chronic kidney disease patients : baseline findings from Chronic Kidney Disease Japan Cohort Study
- Clinical effects of calcium channel blockers and renin-angiotensin-aldosterone system inhibitors on changes in the estimated glomerular filtration rate in patients with polycystic kidney disease
- Chronic Kidney Disease Japan Cohort study : baseline characteristics and factors associated with causative diseases and renal function
- Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility
- Effect of the antiplatelet agent cilostazol on endovascular inflammatory biochemical parameters and the clinical symptoms of peripheral artery disease and restless legs syndrome in hemodialysis patients
- Dexamethasone increases the phosphorylation of nephrin in cultured podocytes
- Genetic differences in the two main groups of the Japanese population based on autosomal SNPs and haplotypes
- A genome-wide association study identifies novel susceptibility genetic variation for thyrotoxic hypokalemic periodic paralysis
- SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population
- A founder mutation of CANT1 common in Korean and Japanese Desbuquois dysplasia
- Induction of remission following a single dose of rituximab alone in a patient with minimal change nephrotic syndrome
- Identification of independent risk loci for Graves' disease within the MHC in the Japanese population
- Long-term beneficial effects of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker therapy for patients with advanced immunoglobulin A nephropathy and impaired renal function
- Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility
- Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population
- A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population
- Clinical outcomes in patients with chronic kidney disease : a 5-year retrospective cohort study at a University Hospital in Japan
- Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
- Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
- Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome
- Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis
- Establishment of a standardized system to perform population structure analyses with limited sample size or with different sets of SNP genotypes
- Making a haplotype catalog with estimated frequencies based on SNP homozygotes
- A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma
- Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
- A case of acute renal failure after exercise with renal hypouricemia demonstrated compound heterozygous mutations of uric acid transporter 1
- Comparison of inhibitors of renin-angiotensin-aldosterone system (RAS) and combination therapy of steroids plus RAS inhibitors for patients with advanced immunoglobulin A nephropathy and impaired renal function
- Circulating levels of soluble α-Klotho in patients with chronic kidney disease
- pHCR : a Parallel Haplotype Configuration Reduction algorithm for haplotype interaction analysis