Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates
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概要
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A new, catalytic enantioselective route to 3-arylindan-1-ones, versatile intermediates for the synthesis of a number of bioactive and pharmaceutically interesting molecules, was developed by exploiting the chiral dirhodium(II) complex-catalyzed intramolecular C-H insertion reaction of α-diazo-β-ketoesters as a key step. Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, proved to be the catalyst of choice for this process, providing enantioselectivities of up to 72% ee.
- The Japan Institute of Heterocyclic Chemistryの論文
- 2006-12-31
The Japan Institute of Heterocyclic Chemistry | 論文
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