<論文>糖残基を有するシロキサン化合物の経皮吸収促進メカニズム

概要

論文の詳細を見る
We have investigated the percutaneous-penetration-enhancing mechanisms of siloxane compounds containing a glucopyranosyl group with various siloxane chain lengths, based on experiments on skin penetration of drugs, effects of cholesterol extraction from the skin and x-ray diffraction. The results of these experiments suggest that the mechanisms of each enhancer are different. The compound with a long siloxane chain increased the partition of drugs into the stratum corneum (SC) through the alteration of skin lipophylicity by adsorption onto the surface without itself penetrating into the SC. The compound with a short siloxane chain also increased the partition of drugs into the SC, although some of the compound penetrated into the SC and extended the hydrophilic pathway between the lipid layers in SC. The compound with disiloxane and alkyl groups increased the partition of drugs into the SC as a result of a defatting effect and penetrated into the SC, which resulted in the increase in the degree of the diffusion of drugs. Furthermore, the percutaneous-penetration enhancement mechanisms of each siloxane enhancer were different from that of oleic acid, which is a typical low-molecular-weight enhancer.
東海大学の論文
2003-03-31