ホスホリルコリン基含有芳香族ポリアミドの合成と生体適合性

概要

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2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer has been reported to be an ideal biocompatible material. In this study, to develop the durability of phosphorylcholine (PC)-containing polymer, the synthesis of novel aromatic diamine compounds containing a PC group with different spacer structures was carried out to prepare aromatic polyamides with a PC moiety. The obtained polymers were soluble in specific solvents such as dimethylsulfoxide (DMSO), N, N-dimethylformamide (DMF) and 1-methyl-2-pyrrolidinone (NMP) at room temperature. This solubility of polymers is an advantage in the processing of medical devices. From the results of X-ray photoelectron spectroscopy (XPS), the P_<2p> peak was clearly observed for the polymer surface coated under moisturized conditions. In addition, it was confirmed from the results of blood-contacting experiments that the PC-containing polyamide films coated under moisturized conditions exhibited blood compatibility, even though the PC content was about 20 mol% in contrast to polyamide without the PC unit.
東海大学の論文