Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection
スポンサーリンク
概要
- 論文の詳細を見る
The mechanisms of severe pneumonia caused by co-infection of bacteria and influenza A virus (IAV) have not been fully elucidated. We examined apoptosis and inflammatory responses in a murine model for pneumococcal pneumonia during IAV infection. Inflammation, respiratory epithelium apoptosis, and inflammatory-cell infiltration increased in a time dependent manner in the lungs of mice co-infected with Streptococcus pneumoniae and IAV, in comparison with those infected with either S. pneumoniae or IAV. According to appearance of terminal deoxynucleotidyl transferase dUTPmediated nick-end labeling positive cells, caspase-3 and -8 were activated 24 h after S. pneumoniae infection, and caspase-3 activation decreased after 48 h, whereas inflammatory cytokine levels continued to increase in co-infected mice. In contrast, in mice infected with either IAV or S. pneumoniae, apoptosis and activation of factors related to caspase-3 peaked at 48 h. Furthermore, Fas-associated death domain was significantly expressed in the lungs of co-infected mice 24 h after S. pneumoniae infection. These data suggest that early onset of apoptosis and its related factors play important roles in fulminant pneumonia resulting from bacterial pneumonia complicated by co-infection with influenza virus.
著者
-
Seki Masafumi
長崎大学 医学部第二内科
-
Maesaki S
Second Department Of Internal Medicine Nagasaki University School Of Medicine
-
Seki Masafumi
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
-
Kosai Kosuke
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedica
-
Tanaka Akitaka
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedical Sciences
関連論文
- Two sporadic cases of infections due to Klebsiella pneumoniae resistant to expanded-spectrum cephalosporins in Japan
- Analysis of Genetic Relationships and Antimicrobial Susceptibility of Verotoxin-Producing Escherichia coli Strains Isolated in Nagasaki Prefecture, Japan in 1996
- Combination Therapy with Miconazole and Flucytosine for Deep-Seated Mycoses
- Lung fibrosis 10 years after cessation of bleomycin therapy.
- Chest Pain and ST Segment Depression Caused by Expansion of Gastric Tube Used for Esophageal Reconstruction
- Synergistic effect of ofloxacin and fluconazole against azole-resistant Candida albicans
- Antifungal activity of a new triazole, voriconazole(UK-109496), against clinical isolates of Aspergillus spp
- Evaluation of Sandwich ELISA Galactomannan Test in Samples of Positive LA Test and Positive Aspergillus Antibody
- Effect of sequential combination of amphotericin B and azole antifungal agents against Aspergillus fumigatus
- Clinical Evaluation of 61 Patients with Pulmonary Aspergilloma
- Aspergillus fumigatus Isolated from Blood Samples of a Patient with Pulmonary Aspergilloma after Embolization
- Invasive Pulmonary Aspergillosis Diagnosed Early by Polymerase Chain Reaction Assay
- A Patient with Fulminant Primary Influenza Pneumonia Which Developed into Secondary Bacterial Pneumonia
- Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.
- Drug Delivery Systems for Infection : Liposome-Incorporating Antimicrobial Drugs
- Detection of Cryptococcus neoformans in Bronchial Lavage Cytology: Report of Four Cases
- Clinical Comparative Study of Sulbactam/Ampicillin and Imipenem/Cilastatin in Elderly Patients with Community-Acquired Pneumonia
- A Patient with Fulminant Influenza-Related Bacterial Pneumonia Due to Streptococcus pneumoniae Followed by Mycobacterium tuberculosis Infection
- Mycobacterium avium Pleuritis in a Non-Immunocompromised Patient
- Disease Severity in Patients with Simultaneous Influenza and Bacterial Pneumonia
- Clinical Features of Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus in a Tertiary Hospital
- Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyushu, Japan
- Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection
- Spontaneous Pyogenic Spondylitis Caused by Klebsiella pneumoniae
- Leukocytoclastic Vasculitis after Pneumococcal pneumonia in an Elderly Adult
- Three Cases of Concurrent Infection with Mycobacterium tuberculosis and Cryptococcus neoformans