Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.
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概要
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Platelet-activating factor (PAF) is a critical mediator of severe inflammatory diseases such as pneumonia, and the PAF-receptor (PAFR) is known to be an anchor for Streptococcus pneumoniae attachment to lung epithelial cells. We conducted a DNA microarray analysis to detect critical factors that mediate fulminant pneumonia due to influenza virus and S. pneumoniae co-infection in mice. Among the factors detected, levels of PAF-acetyl hydrolase (PAF-AH), which functions as inactivated PAF, were significantly increased, and PAFR was expressed in co-infected mouse lungs, as compared to the respective levels in mice infected with either S. pneumoniae or virus alone. Significantly elevated PAF-AH enzymatic activity was observed in the co-infected mouse lung, suggesting that co-infection activated PAF-related factors. These findings suggest that PAF and related molecules play important roles in fulminant pneumonia due to influenza virus infection, especially when severe bacterial pneumonia is complicated by co-infection with influenza virus.
- National Institute of Infectious Diseasesの論文
著者
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Seki Masafumi
長崎大学 医学部第二内科
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Maesaki S
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Saito Masataka
北九州市立八幡病院
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Seki Masafumi
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Kosai Kosuke
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedica
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Hara Atsuko
Department Of Respiratory Diseases Nagasaki University Graduate School Of Biomedical Sciences
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