薬物の経皮吸収促進法の開発

概要

論文の詳細を見る
The potential of transdermal drug delivery systems has been developed in recent years with the approval of several medicines for use by patients who are unable to use conventional dosage routes, like oral administration or injection. To enhance the transdermal drug delivery system potential to other drug candidates, many researchers have been exploring enhancement approaches to increase the permeability of various drugs through the skin. Iontophoresis is a very attractive way of delivering ionized drugs by the application of an electric field to the skin. Electroporation is also an attractive method to deliver a drug through the skin using pulsed current. In this study, significant and synergistic effects of both methods were demonstrated. Besides these technologies, various physical approaches are under study. Such technologies can be expected to deliver not only small molecular wheit compounds but also macromolecules like poly peptides.