Measurement of Single-Cell Deformability Using Impedance Analysis on Microfluidic Chip

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概要

• 論文の詳細を見る

• In this paper, we propose a microfluidic chip that measures the deformability of single cells by an impedance measurement method. The proposed chip is designed to differentiate the deformability of various cells by measuring the length of their stretched membrane indirectly according to the variation of the impedance after applying aspiration pressure to the cell membrane. The length of the stretched cell membrane is proportional to the applied pressure. Lengths of 18 and 21 μm were observed at the same suction pressure for human breast normal cells (MCF-10A) and caner cells (MCF-7), respectively. Electrical measurement was performed using an impedance analyzer at various frequencies. Results revealed that the impedance measurement method can be used to analyze the biomechanical characteristics of single cells, which indicates the state of malignancy of cells.

• Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
• 2010-12-25

著者

• Park Jungyul

  Department Of Mechanical Engineering Sogang University

• Yun Kwang-seok

  Department Of Electrical Engineering And Computer Science Korea Advanced Institute Of Science And Te

• Lee Sangho

  School Of Electrical Engineering And Computer Science Kyungpook National University

• Yun Kwang-Seok

  Department of Electronic Engineering, Sogang University, 1 Shinsu-dong, Mapo-gu, Seoul 121-742, Korea

• Choi Sung

  School of Chemical Engineering and Materials Science, Chung-Ang University, Huksuk-dong 221, Dongjak-gu, Seoul 156-756, Korea

• Park Jungyul

  Department of Mechanical Engineering, Sogang University, 1 Shinsu-dong, Mapo-gu, Seoul 121-742, Korea

• Kim Dongil

  Department of Electronic Engineering, Sogang University, 1 Shinsu-dong, Mapo-gu, Seoul 121-742, Korea

• Choi Eunpyo

  Department of Mechanical Engineering, Sogang University, 1 Shinsu-dong, Mapo-gu, Seoul 121-742, Korea

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