Microbubble Adhesion to Target Wall by Ultrasonic Wave Frequency Sweep Method

概要

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Microbubble cavitation enhances the permeability of cell membranes if the bubbles are in the vicinity of the target. A method aimed at attaching microbubbles to a target wall using the frequency sweep of an ultrasonic pumping wave is proposed. A slow frequency decrease of the pumping ultrasonic wave moves the aggregated bubbles toward the surrounding target wall. The following quick frequency return rearranges the spatial distribution of the bubble aggregations. Repetition of this sequence increases the number of bubbles adhering to the target wall. To analyze the rearrangement by the quick frequency return, Numerical analyses are carried out based on a three-dimensional model in which bubble-to-bubble interaction caused by the secondary Bjerknes force is taken into account. Experiments are carried out using ultrasonic contrast agent microbubbles. As a result, we obtain twice the trapping efficiency of the microbubble with the frequency sweep method from 2.5 to 1.75 MHz in comparison with the fixed frequency method at 2.1 MHz.
Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
2009-07-25