高血圧患者におけるロサルタンとカンデサルタンの尿酸代謝に及ぼす作用に関する比較検討

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Thirty-one hypertensive outpatients randomly and orally administered losartan (50mg, n=15) or candesaratan (8mg, n=16). Blood and urine samples were collected before and up to 3 months administration. Blood pressure was lowered relatively and significantly using either losartan or candesartan.<BR>Losartan decreased serum uric acid concentration significantly (from6.6±1.4mg/dl to 6.0±1.2mg/dl, P<0.05), while candesartan did not (from 6.1±1.0to 6.2±15mg/dl). In 6 of 17 subjects,1.0mg/dl of uric acid reduction was achieved. Losartan also induced an increase in fractional excretion of uric acid significantly, while canderartan did not.<BR>According to these findings, losa rtan, which has a high affinity for the urate/anion exchanger, induces a significant decrease in uric acid in hypertensive patients. The pleiotrophic effects of losartan on uric acid metabolism might contribute to cardiovascular risk reduction, according to recent world-wide clinical investigations.
Japanese Society of Gout and Nucleic Acid Metabolismの論文