Lowered Postoperative Ldl-C/Hdl-C Ratio Reduces Later Cardiovascular Events after Abdominal Aortic Aneurysm Surgery
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概要
- 論文の詳細を見る
Purpose: To examine the relationship between the incidence of later cardiovascular events after abdominal aortic aneurysm (AAA) surgery and postoperative lipid levels.Methods: Atherosclerotic risk factors including postoperative serum lipid levels were examined in 116 patients aged 70 or less undergoing an elective AAA surgery. Later cardiovascular events after AAA surgery occurred in 21 patients, including cerebral infarction (n = 4), catheter intervention or surgery for coronary artery disease (CAD) (n = 10) and other vascular disease.Results: Postoperative cholesterol levels during the average follow-up period of 55.6 ± 44.3 (months) were 49.0 ± 15.7 (mg/dL) for high-density lipoprotein cholesterol (HDL-C), 97.9 ± 31.2 (mg/dL) for low-density lipoprotein cholesterol (LDL-C), which were both significantly improved compared to preoperative values (p <0.001). Cox hazard analysis indicated that preexistent CAD significantly increased in the risk for later cardiovascular events (hazard ratio 5.67; 95%CI 1.92-16.8; p = 0.002) and lowered postoperative LDL-C/HDL-C ratio <1.5 decreased in the risk after AAA surgery (hazard ratio 0.10; 95%CI 0.01-0.83; p = 0.033). Patients with postoperative LDL-C/HDL-C ratio <1.5 (n = 22) had a significantly better cardiovascular event-free rate than those with that ratio >=1.5 (n = 94) (p = 0.014).Conclusion: Lowered postoperative LDL-C/HDL-C ratio <1.5 can decrease in the risk for later cardiovascular events after AAA surgery. These results may support the rationale for postoperative aggressive lipid-modifying therapy.
- 日本脈管学会、日本血管外科学会、日本静脈学会の論文
著者
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Ishii Kouji
Division Of Electrical And Computer Engineering Faculty Of Engineering Yokohama National University:
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Matsui Yoshiro
Department Of Cardiac Surgery Hokkaido University Hospital
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Sasaki Shigeyuki
Division Of Medical Science Health Sciences University Of Hokkaido
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Gohda Toshihiro
Division Of Cardiovascular Surgery Aishin Memorial Hospital
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Takahashi Junichiro
Division Of Cardiovascular Surgery Aishin Memorial Hospital
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Wakamatsu Yutaka
Division Of Cardiovascular Surgery Aishin Memorial Hospital
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Kanaoka Tsuyoshi
Division Of Cardiovascular Surgery Aishin Memorial Hospital
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Kanaoka Tsuyoshi
Division of Cardiovascular Surgery, Aishin Memorial Hospital, Sapporo, Hokkaido, Japan
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