Late Hematological Improvement of Myelodysplastic Syndrome Following Treatment with 5-Azacitidine Therapy
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概要
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Recently, 5-azacitidine has been reported to improve the survival of patients with high-risk myelodysplastic syndrome (MDS) and was approved for the treatment of MDS in Japan. We herein report a case of high-risk MDS in which the patient exhibited a hematological improvement three months after the first cycle of 5-azacitidine therapy. The second cycle of 5-azacitidine was not administered due to a severe pulmonary infection. Bone marrow aspiration revealed a decrease in the level of blast cells from 7.0% to 0.7%, and the subclassification of MDS improved from refractory anemia with excess blasts (RAEB)-1 to refractory cytopenia with unilineage dysplasia. This case demonstrates a possible late effect of 5-azacitidine treatment.
- 一般社団法人 日本内科学会の論文
著者
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Hangaishi Akira
Department Of Hematology And Oncology Graduate School Of Medicine The University Of Tokyo
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Kida Michiko
Department of Hematology, NTT Medical Center Tokyo, Japan
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Takaoka Kensuke
Department of Hematology, NTT Medical Center Tokyo, Japan
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Ito Ayumu
Department of Hematology, NTT Medical Center Tokyo, Japan
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Morioka Takehiko
Department of Hematology, NTT Medical Center Tokyo, Japan
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Usuki Kensuke
Department of Hematology, NTT Medical Center Tokyo, Japan
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