Edge Vascular Response After Polymer-Free vs. Polymer-Based Paclitaxel-Eluting Stent Implantation:– Serial Intravascular Ultrasound Study From the Late Incomplete Stent Apposition Evaluation (LISA) Trial –

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概要

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• Background:It is unknown if lack of polymer can provoke a different edge response in drug-eluting stents. The aim of this study was to compare edge vascular response between polymer-free paclitaxel-eluting stent (PF-PES) and polymer-based paclitaxel-eluting stents (PB-PES).Methods and Results:A total of 165 eligible patients undergoing percutaneous coronary intervention were prospectively randomized 1:1 to receive either PF-PES or PB-PES. Those patients with paired intravascular ultrasound (IVUS) after procedure and at 9-month follow-up were included in this analysis.Seventy-six patients with 84 lesions, divided into PB-PES (38 patients, 41 lesions) and PF-PES groups (38 patients, 43 lesions) had paired post-procedure and 9-month follow-up IVUS and were therefore included in this substudy. There was a significant lumen decrease at the proximal edge of PF-PES (from 9.02±3.06 mm2to 8.47±3.05 mm2; P=0.040), and a significant plaque increase at the distal edges of PF-PES (from 4.39±2.73 mm2to 4.78±2.63 mm2; P=0.004). At the distal edge there was a significant plaque increase in the PF-PES compared to PB-PES (+8.0% vs. –0.6%, respectively; P=0.015) with subsequent lumen reduction (–5.2% vs. +6.0%, respectively; P=0.024).Conclusions:PF-PES had significant plaque increase and lumen reduction at the distal edge as compared to PB-PES, probably due to difference in polymer-based drug-release kinetics between the 2 platforms.

• 一般社団法人 日本循環器学会の論文

著者

• Garcia Del

  Department Of Anatomy And Cell Biology Kochi Medical School

• Diaz Jose

  Department of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

• Martin-Yuste Victoria

  Thorax Institute, Hospital Clinic

• Brugaletta Salvatore

  Thorax Institute, Hospital Clinic

• Sabaté Manel

  Thorax Institute, Hospital Clinic

• Shiratori Yoshitaka

  Thorax Institute, Department of Cardiology, Hospital Clinic, IDIBAPS, University of Barcelona

• Otsuki Shuji

  Thorax Institute, Department of Cardiology, Hospital Clinic, IDIBAPS, University of Barcelona

• Cola Clarissa

  Department of Cardiology, Sant Pau Hospital

• Ruiz-Salmeron Rafael

  Department of Cardiology, Virgen de Macarena Hospìtal

• Pinar Eduardo

  Department of Cardiology, Virgen de la Arrixaca Hospital

• Martí Vicens

  Department of Cardiology, Sant Pau Hospital

• García-Picart Juan

  Department of Cardiology, Sant Pau Hospital

• Sabaté Manel

  Thorax Institute, Department of Cardiology, Hospital Clinic, IDIBAPS, University of Barcelona

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• Edge Vascular Response After Polymer-Free vs. Polymer-Based Paclitaxel-Eluting Stent Implantation:– Serial Intravascular Ultrasound Study From the Late Incomplete Stent Apposition Evaluation (LISA) Trial –

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