レセプトデータを用いたスタチン系薬剤による睡眠障害のリスクに関する解析

概要

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Objective: To examine the association between statin use and the risk of sleep disturbances, data mining was performed on a claims database. Methods: Symmetry analysis was carried out to identify the risk of sleep disturbances after statin use during the period from January 2005 to December 2011. Statin use in combination with hypnotic drugs was examined by prescription sequence symmetry analysis. In this study, hypnotic drugs that are commonly prescribed for the treatment of insomnia were used as markers of sleep disturbances produced by statins. Likewise, event sequence symmetry analysis was undertaken to evaluate the association between statin use and the diagnosis of sleep disturbances.Results: Significant associations of statin use with short-acting hypnotic drugs were found, with an adjusted SR (sequence ratio) of 1.23 (95%CI: 1.04-1.45) at an interval of 12 months. Otherwise, significant associations between individual statin use and hypnotic drug use were not found. Significant associations between use of statins and the diagnosis of sleep disturbances were not also found in this study.Conclusions: Analysis of the claim database demonstrated that statin therapy might be associated with an emergence of sleep disturbances. Therefore, individuals prescribed statins should be considered as having an increased risk of sleep disturbances.
日本医薬品情報学会の論文