The Relationship Between the Perioperative Transition of Serum Anticholinergic Activity and Postoperative Delirium in Patients Undergoing Esophagectomy and Gastrectomy
スポンサーリンク
概要
- 論文の詳細を見る
Purpose: Delirium is one of the most common postoperative complications among elderly patients undergoing major surgery. However, biomarkers for delirium have not yet been elucidated. We therefore investigated the relationship between postoperative delirium and the serum anticholinergic activity (SAA).Materials: Patients undergoing elective esophagectomy or gastrectomy under combined thoracic epidural and general anesthesia were prospectively studied.Methods: The levels of SAA were measured inside the operating room after the induction of anesthesia before the surgery began, and immediately after the surgery had finished, but before the patient awoke from anesthesia. The occurrence of postoperative delirium was determined using the Confusion Assessment Method (CAM).Results: Postoperative delirium was identified in 41.2% of the 34 patients enrolled in this study. Compared with the non-delirious group, the delirious group had a significantly higher number of preoperatively SAA (+) patients whose elevated SAA levels were still detectable after surgery (p < 0.05).Conclusions: Patients who had incomplete or no ability to compensate for the elevated anticholinergic activity were more likely to develop postoperative delirium.
- 順天堂医学会の論文
著者
-
Nagaoka Isao
Department Of Host Defense And Biochemical Research Juntendo University School Of Medicine
-
Inada Eiichi
Department Of Anesthesiology And Pain Medicine Juntendo University School Of Medicine
-
Hori Koji
Department Of Clinical Research National Shimofusa Hospital
-
Kitajima Yuka
Department Of Life Science Graduate School Of Life Science University Of Hyogo
-
Kajiyama Yoshiaki
Department Of Esophageal & Gastroenterological Surgery Juntendo University
-
Someya Akimasa
Department Of Host Defense And Biochemical Research Juntendo University School Of Medicine
-
Yamaguchi Keisuke
Department Of Anesthesiology And Pain Medicine Juntendo University School Of Medicine
-
Murakami Taisuke
Department Of Host Defense And Biochemical Research Juntendo University School Of Medicine
-
Hachisu Mitsugu
Department Of Clinical Psychopharmacy School Of Pharmaceutical Sciences Showa University
-
KONISHI Kimiko
Tokyo Metropolitan Tobu Medical Center for Persons with Developmental/Multiple Disabilities
-
Hara Atsuko
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
-
YAMAGUCHI KEISUKE
Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine
関連論文
- Role of ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor in macrophage phagocytosis
- Antimicrobial cathelicidin polypeptide CAP11 suppresses the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice
- Complete remission of splenic marginal zone lymphoma after an acute flare-up of hepatitis B in a hepatitis B virus carrier
- Subepithelial extension of squamous cell carcinoma in the esophagus : Histopathological study using D2-40 immunostaining for 108 superficial carcinomas
- IS4-01 Indications for thoracoscopic repair of congenital diaphragmatic hernia in neonates(Respiratory System/Emergency,Share Smiles with Sick Children, Dreams and Innovation for Pediatric Surgery)
- The degree of newly emerging mitral regurgitation during off-pump coronary artery bypass is predicted by preoperative left ventricular function
- Anesthesia protocols for early vitrectomy in former preterm infants diagnosed with aggressive posterior retinopathy of prematurity
- Cord blood transplantation with a reduced-intensity conditioning regimen for patients with relapsed aggressive multiple myeloma after cytoreduction with bortezomib
- Electrogastrography during and after cesarean delivery
- Preoperative plasma brain natriuretic peptide level is an independent predictor of postoperative atrial fibrillation following off-pump coronary artery bypass surgery
- Anesthetic management of a patient with severe heart failure undergoing total gastrectomy
- Pick's disease with Pick bodies : An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron
- Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells
- Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli
- Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats
- Revascularization Using Satellite Vein after Radial Artery Harvested for Coronary Artery Bypass Grafting
- The effect of antibacterial peptide human β-defensin-2 on interleukin-18 secretion by keratinocytes
- Epithelial cell-derived human β-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway
- Importance of Controlling Drug-resistant Pseudomonas aeruginosa Infection: Experience from Lung Transplantation in a Cystic Fibrosis Case
- Evaluation of the effect of human β-defensins on neutrophil apoptosis
- A Patient with Fulminant Influenza-Related Bacterial Pneumonia Due to Streptococcus pneumoniae Followed by Mycobacterium tuberculosis Infection
- Low potency of Chlamydophila LPS to activate human mononuclear cells due to its reduced affinities for CD14 and LPS-binding protein
- Measurement of Activities of Human Serum Sulfotransferases Which Transfer Sulfate to the Galactose Residues of Keratan Sulfate and to the Nonreducing End N-Acetylglucosamine Residues of N-Acetyllactosamine Trisaccharide: Comparison between Normal Controls
- First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early-onset Alzheimer's disease : Comparison with senile dementia of Alzheimer's type
- Donepezil-responsive alcohol-related prolonged delirium
- 'Awakenings' in demented patients
- Effect of glucosamine on Interleukin-8 production from human colonic epithelial cell line
- Lymphatic invasion according to D2-40 immunostaining is a strong predictor of nodal metastasis in superficial squamous cell carcinoma of the esophagus : Algorithm for risk of nodal metastasis based on lymphatic invasion
- Assessment of pharmacological toxicity using serum anticholinergic activity in a patient with dementia
- In vivo Evaluation of a Novel Chitosan/HAp Composite Biomaterial as a Carrier of rhBMP-2
- CHARACTERIZATION OF GONADOTROPIN-RELEASING HORMONE (GnRH) RECEPTORS OF THE ASCIDIAN CIONA INTESTINALIS(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- CHARACTERIZATION OF GONADOTROPIN-RELEASING HORMONE RECEPTORS FOUND IN THE NEURAL COMPLEX OF THE ASCIDIAN CIONA INTESTINALIS(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Preventive Effect of Lactoferrin Intake on Anemia in Female Long Distance Runners
- A case of cardiac herniation after extrapleural pneumonectomy for malignant thymoma
- Inhibitory effect of oral glucosamine administration on platelet activation in guinea pigs
- Gastrointestinal stromal tumor in a child and review of the literature
- RECTAL GRANULAR-CELL TUMOR DIFFICULT TO DISTINGUISH FROM CARCINOID TUMOR
- Crystallization of Calcium Phosphate Templated by α-Amino Acids Depending on Their Composition, Chain Length, and Enantiomerism
- The effect of one-lung ventilation upon pulmonary inflammatory responses during lung resection
- The Reality and the Reliability of Esophageal Cancer Treatment : Which Will You Choose for Yourself?
- LOCAL ANESTHETIC ACTIVITY OF 1-(MORPHOLINO OR PIPERIDINO)-2-PROPANOL DERIVATIVES
- P-290 Thoracoscopic plication for diaphragmatic eventration in a neonate
- Adverse effects of anticholinergic activity on cognitive functions in Alzheimer's disease
- アルツハイマー病患者の行動学的症候における老化の影響
- Immediate Single Lobar Retransplantation for Primary Graft Dysfunction After Living-Donor Lobar Lung Transplantation : Report of a Case
- Current status of primary malignant melanoma of the esophagus : clinical features, pathology, management and prognosis
- Effects of sevoflurane and propofol on pulmonary inflammatory responses during lung resection
- Thoracoscopic Plication for Diaphragmatic Eventration in a Neonate
- The Relationship Between the Perioperative Transition of Serum Anticholinergic Activity and Postoperative Delirium in Patients Undergoing Esophagectomy and Gastrectomy